Identification of a functional DNA binding site for the SREBP-1c transcription factor in the first intron of the human caspase-2 gene
| Autor: | Laurent Corcos, Eric Solary, Emmanuelle Logette |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Transcriptional Activation
endocrine system Response element Biology digestive system polycyclic compounds Humans Molecular Biology Transcription factor Cells Cultured Genetics Binding Sites Caspase 2 Intron food and beverages Promoter DNA Cell Biology TCF4 Introns Sterol regulatory element-binding protein DNA binding site Caspases TAF2 lipids (amino acids peptides and proteins) Sterol Regulatory Element Binding Protein 1 Sterol Regulatory Element Binding Protein 2 |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1738:1-5 |
| ISSN: | 1388-1981 |
| DOI: | 10.1016/j.bbalip.2005.11.006 |
| Popis: | Sterol Regulatory Element Binding Proteins (SREBP) are transcription factors that regulate lipid synthesis. We have shown recently that the human CASP-2 gene, encoding procaspase-2, was under the positive control of SREBP-2 that transactivates several responsive elements in the promoter region. We describe here the function of an additional SREBP-responsive element located in the first intron. Remarkably, this site is uniquely responsive to SREBP-1c that is mainly involved in fatty acids synthesis. This observation, together with our recent findings, strengthens the notion that the CASP-2 gene belongs to the SREBP-responsive gene battery in human cells. |
| Databáze: | OpenAIRE |
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