Molecular Aspects concerning the Use of the SARS-CoV-2 Receptor Binding Domain as a Target for Preventive Vaccines
| Autor: | Yury Valdés-Balbín, Fabrizio Chiodo, Lila Castellanos-Serra, Françoise Paquet, Belinda Sánchez Ramírez, Yanet Climent, Sonsire Fernández, Laura Rodriguez, Kalet León, Vicente Verez-Bencomo, Daniel G. Rivera, Guang-Wu Chen, Darielys Santana-Mederos, Raine Garrido, Dagmar García-Rivera, Tays Hernández |
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| Přispěvatelé: | Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Molecular cell biology and Immunology, Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
General Chemical Engineering
[SDV]Life Sciences [q-bio] Biology 010402 general chemistry 01 natural sciences Epitope Neutralization Virus law.invention Immune system Antigen law Neutralizing antibody QD1-999 ComputingMilieux_MISCELLANEOUS chemistry.chemical_classification 010405 organic chemistry General Chemistry Virology 3. Good health 0104 chemical sciences Chemistry chemistry Recombinant DNA biology.protein Glycoprotein Outlook |
| Zdroj: | ACS Central Science ACS Central Science, ACS Publications, 2021, 7 (5), pp.757-767. ⟨10.1021/acscentsci.1c00216⟩ ACS Central Science, Vol 7, Iss 5, Pp 757-767 (2021) ACS Central Science, 7(5), 757-767. American Chemical Society ACS Central Science, ACS Publications, In press, ⟨10.1021/acscentsci.1c00216⟩ Valdes-Balbin, Y, Santana-Mederos, D, Paquet, F, Fernandez, S, Climent, Y, Chiodo, F, Rodríguez, L, Sanchez Ramirez, B, Leon, K, Hernandez, T, Castellanos-Serra, L, Garrido, R, Chen, G W, Garcia-Rivera, D, Rivera, D G & Verez-Bencomo, V 2021, ' Molecular Aspects concerning the Use of the SARS-CoV-2 Receptor Binding Domain as a Target for Preventive Vaccines ', ACS Central Science, vol. 7, no. 5, pp. 757-767 . https://doi.org/10.1021/acscentsci.1c00216 |
| ISSN: | 2374-7943 2374-7951 |
| Popis: | The development of recombinant COVID-19 vaccines has resulted from scientific progress made at an unprecedented speed during 2020. The recombinant spike glycoprotein monomer, its trimer, and its recombinant receptor-binding domain (RBD) induce a potent anti-RBD neutralizing antibody response in animals. In COVID-19 convalescent sera, there is a good correlation between the antibody response and potent neutralization. In this review, we summarize with a critical view the molecular aspects associated with the interaction of SARS-CoV-2 RBD with its receptor in human cells, the angiotensin-converting enzyme 2 (ACE2), the epitopes involved in the neutralizing activity, and the impact of virus mutations thereof. Recent trends in RBD-based vaccines are analyzed, providing detailed insights into the role of antigen display and multivalence in the immune response of vaccines under development. SARS-CoV-2 receptor-binding domain (RBD)-specific antibodies are crucial for neutralizing efficacy. Emerging mutations, the quality of the IgG response, and the benefit of multivalent display are analyzed here for RBD subunit vaccines. |
| Databáze: | OpenAIRE |
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