Progesterone change in the late follicular phase affects pregnancy rates both agonist and antagonist protocols in normoresponders: a case-controlled study in ICSI cycles
| Autor: | Leyla Mollamahmutoglu, Berfu Demir, Serdar Dilbaz, Inci Kahyaoglu, Neslihan Yerebasmaz, Altay Guvenir, Sadiman Kiykac Altinbas, Berna Dilbaz |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Luteinizing hormone Leuprorelin Pregnancy Rate Sperm Injections Endocrinology Diabetes and Metabolism medicine.medical_treatment intracytoplasmic sperm injection Gonadorelin Antagonists and inhibitors Hormone antagonist Procedures In-vitro fertilization Gonadotropin-Releasing Hormone Follicular phase 0302 clinical medicine Endocrinology Pregnancy GnRH antagonist Medicine Ganirelix GnRH agonist reproductive and urinary physiology Progesterone Priority journal Analogs and derivatives 030219 obstetrics & reproductive medicine Estradiol Progesterone in Late Follicular Phase and Pregnancy Rates Incidence Follicle stimulating hormone Obstetrics and Gynecology Gonadotropin-releasing hormone Embryo transfer Intracytoplasmic Chorionic gonadotropin Blood Follicular Phase in-vitro fertilization Female hormones hormone substitutes and hormone antagonists Human Agonist Adult medicine.medical_specialty endocrine system medicine.drug_class Ovulation induction Case control study Major clinical study Case-control studies Luteal phase progesterone Article Intracytoplasmic sperm injection 03 medical and health sciences Hormone Antagonists Ovulation Induction Internal medicine Humans Sperm Injections Intracytoplasmic Cetrorelix In vitro fertilisation urogenital system business.industry Fertilization in vitro Antagonist Hormone antagonists Luteinizing Hormone Follitropin Embryo Transfer Pregnancy rate 030104 developmental biology Case-Control Studies Progesterone blood level Follicle Stimulating Hormone Leuprolide business Controlled study Gonadorelin agonist |
| Zdroj: | Gynecological Endocrinology |
| Popis: | Objective: The aim of the presented study is to investigate the impact of progesterone change in the late follicular phase on the pregnancy rates of both agonist and antagonist protocols in normoresponders. Study design: A total of 201 normoresponder patients, who underwent embryo transfer were consecutively selected. 118 patients were stimulated using a long luteal GnRH agonist protocol and 83 using a flexible antagonist protocol. The level of change in late follicular phase progesterone was calculated according to the progesterone levels on the hCG day and pre-hCG day (1 or 2 days prior to hCG day) measurement. Results: Clinical pregnancy rates were comparable between long luteal and antagonist group (35.6 and 41%, respectively). The incidence of progesterone elevation on the hCG day was 11% in long luteal and 18% in antagonist group (p = 0.16). In pregnant cycles, p levels both on the hCG day and pre-hCG day measurement were significantly higher in antagonist than agonist cycles (p = 0.029, p = 0.038, respectively). The change of p level was statistically significant in non-pregnant cycles both for the agonist (-0.17 ± 0.07; 95% CI: −0.29 to −0.37) and antagonist groups (−0.18 ± 0.07; 95%CI: −0.31 to −0.04). Conclusions: Late follicular phase progesterone levels were stable during the cycles of pregnant patients irrespective of the protocols and were shown to be higher in pregnant patients in antagonist cycles when compared to agonist cycles. |
| Databáze: | OpenAIRE |
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