Treatment of iron overload syndrome: a general review
| Autor: | Tadeu Gonçalves de Lima, Fernanda Luna Neri Benevides, Flávio Lima Esmeraldo Filho, Igor Silva Farias, Diovana Ximenes Cavalcante Dourado, Eveline Gadelha Pereira Fontenele, Maria Elisabete Amaral de Moraes, Ana Rosa Pinto Quidute |
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| Rok vydání: | 2019 |
| Předmět: |
Medicine (General)
medicine.medical_specialty Iron Overload Iron deposition Iron Chelating Agents 03 medical and health sciences R5-920 0302 clinical medicine Phlebotomy Humans Medicine Intensive care medicine Patient compliance Hemochromatosis business.industry Organ dysfunction Syndrome General Medicine medicine.disease 030220 oncology & carcinogenesis Hereditary hemochromatosis Etiology Patient Compliance 030211 gastroenterology & hepatology medicine.symptom business |
| Zdroj: | Revista da Associação Médica Brasileira v.65 n.9 2019 Revista da Associação Médica Brasileira Associação Médica Brasileira (AMB) instacron:AMB Revista da Associação Médica Brasileira, Vol 65, Iss 9, Pp 1216-1222 (2019) |
| ISSN: | 1806-9282 0104-4230 |
| DOI: | 10.1590/1806-9282.65.9.1216 |
| Popis: | SUMMARY INTRODUCTION Iron overload is a broad syndrome with a large spectrum of causative etiologies that lead to iron deposition. When iron exceeds defenses, it causes oxidative damage and tissular disfunction. Treatment may prevent organ dysfunction, leading to greater life expectancy. METHODS Literature from the last five years was reviewed through the use of the PubMed database in search of treatment strategies. DISCUSSION Different pharmacological and non-pharmacological strategies are available for the treatment of iron overload and must be used according to etiology and patient compliance. Therapeutic phlebotomy is the basis for the treatment of hereditary hemochromatosis. Transfusional overload patients and those who cannot tolerate phlebotomy need iron chelators. CONCLUSION Advances in the understanding of iron overload have lead to great advances in therapies and new pharmacological targets. Research has lead to better compliance with the use of oral chelators and less toxic drugs. |
| Databáze: | OpenAIRE |
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