The Staphylococcus-Specific Gene rsr Represses agr and Virulence in Staphylococcus aureus
| Autor: | Dindo Reyes, Guido Memmi, Sandeep Tamber, Joseph D. Schwartzman, Niles P. Donegan, Ambrose L. Cheung |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Staphylococcus aureus Transcription Genetic Genetic Linkage Virulence Factors RNAIII Immunology Mutant Virulence Locus (genetics) Biology medicine.disease_cause Microbiology Mice Bacterial Proteins Transcription (biology) medicine Animals Gene Genetics Effector Gene Expression Regulation Bacterial biochemical phenomena metabolism and nutrition Molecular Pathogenesis Mice Inbred C57BL RNA Bacterial Infectious Diseases Trans-Activators bacteria Staphylococcal Skin Infections Parasitology |
| Zdroj: | Infection and Immunity. 78:4384-4391 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.00401-10 |
| Popis: | The expression of virulence factors in Staphylococcus aureus is tightly coordinated by a vast network of regulatory molecules. In this report, we characterize a genetic locus unique to staphylococci called rsr that has a role in repressing two key virulence regulators, sarR and agr . Using strain SH1000, we showed that the transcription of virulence effectors, such as hla , sspA , and spa , is altered in an rsr mutant in a way consistent with agr upregulation. Analysis of RNAIII expression of the agr locus in rsr and rsr-sarR mutants indicated that rsr likely contributes to agr expression independently of SarR. We also provide evidence using a murine model of S. aureu s skin infection that the effects mediated by rsr reduce disease progression. |
| Databáze: | OpenAIRE |
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