Therapeutic Hydrogel Patch to Treat Atopic Dermatitis by Regulating Oxidative Stress

Autor:	Ye Eun Kim, Seung Woo Choi, Min Kyung Kim, Thanh Loc Nguyen, Jaeyun Kim
Rok vydání:	2022
Předmět:	Mice Oxidative Stress Mechanical Engineering Animals Cytokines Hydrogels General Materials Science Bioengineering General Chemistry Reactive Oxygen Species Condensed Matter Physics Dermatitis Atopic Skin
Zdroj:	Nano Letters. 22:2038-2047
ISSN:	1530-6992 1530-6984
Popis:	Atopic dermatitis (AD) is a chronic inflammatory disease associated with unbalanced immune responses in skin tissue. Although steroid drugs and antihistamines are generally used to treat AD, continuous administration causes multiple side effects. High oxidative stress derived from reactive oxygen species (ROS) has been implicated in the pathogenesis of AD. A high level of ROS promotes the release of pro-inflammatory cytokines and T-cell differentiation, resulting in the onset and deterioration of AD. Here, we report a therapeutic hydrogel patch suppressing the high oxidative stress generated in AD lesions. The hydrogel embedded with ROS-scavenging ceria nanoparticles leads to the decrease of both extracellular and intracellular ROS and exhibits cytoprotective effects in a highly oxidative condition. AD-induced mouse model studies show enhanced therapeutic outcomes, including a decrease in the epidermal thickness and levels of AD-associated immunological biomarkers. These findings indicate that a ROS-scavenging hydrogel could be a promising therapeutic hydrogel patch for treating and managing AD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd12ce81f97f3faee5d006c5e69c5a3 https://doi.org/10.1021/acs.nanolett.1c04899 Zobrazit plný text záznamu