Design of conformationally rigid dimeric MRI agents
| Autor: | Shukla R, Pillai Radhakrishna, Ratsep Pc, Ramachandran S. Ranganathan, Michael F. Tweedle, Zhang X, Maria Fernandez |
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| Rok vydání: | 1996 |
| Předmět: |
Flexibility (anatomy)
Stereochemistry Dimer Molecular Conformation Contrast Media Linkage (mechanical) Magnetic Resonance Imaging law.invention Magnetics Paramagnetism chemistry.chemical_compound medicine.anatomical_structure chemistry law medicine Radiology Nuclear Medicine and imaging Chelation Chelating Agents |
| Zdroj: | Magnetic Resonance in Medicine. 35:928-931 |
| ISSN: | 1522-2594 0740-3194 |
| DOI: | 10.1002/mrm.1910350623 |
| Popis: | The conformational flexibility of the linkage mechanism or tether between paramagnetic metal centers is explored to assess optimal structural characteristics of multimeric MRI contrast agents. Two dimeric paramagnetic chelates differing in linkage flexibility but similar in symmetry are compared. Relaxivity, water hydration number, and reorientational times of the chelate groups are obtained, and the results demonstrate that greater linkage flexibility reduces overall relaxivity. |
| Databáze: | OpenAIRE |
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