Mapping Large-Scale Networks Associated with Action, Behavioral Inhibition and Impulsivity
| Autor: | Jyoti Mishra, Nathalie Buscher, T. Tang, A. Gupta, Pragathi Priyadharsini Balasubramani, Leila Fakhraei, M. Francoeur, C. Claros, S. Hulyalkar, Z Xu, H Xiong, Dhakshin S. Ramanathan, A. Terry |
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| Rok vydání: | 2021 |
| Předmět: |
1.2 Psychological and socioeconomic processes
Brain activity and meditation 1.1 Normal biological development and functioning Prefrontal Cortex impulsivity Sensory system local field potentials Biology Basic Behavioral and Social Science Premotor cortex Behavioral and Social Science medicine Prefrontal cortex Inhibition Brain Mapping General Neuroscience Ventral striatum Motor Cortex Neurosciences Brain General Medicine Brain Disorders Inhibition Psychological Mental Health behavioral inhibition medicine.anatomical_structure Cognition and Behavior nervous system Neurological Impulsive Behavior oscillations Psychological brain mapping Orbitofrontal cortex Primary motor cortex orbitofrontal cortex Neuroscience Research Article: New Research Motor cortex |
| Zdroj: | eNeuro, vol 8, iss 1 eNeuro |
| ISSN: | 2373-2822 |
| Popis: | A key aspect of behavioral inhibition is the ability to wait before acting. Failures in this form of inhibition result in impulsivity and are commonly observed in various neuropsychiatric disorders. Prior evidence has implicated medial frontal cortex, motor cortex, orbitofrontal cortex (OFC), and ventral striatum in various aspects of inhibition. Here, using distributed recordings of brain activity [with local-field potentials (LFPs)] in rodents, we identified oscillatory patterns of activity linked with action and inhibition. Low-frequency (δ) activity within motor and premotor circuits was observed in two distinct networks, the first involved in cued, sensory-based responses and the second more generally in both cued and delayed actions. By contrast, θ activity within prefrontal and premotor regions (medial frontal cortex, OFC, ventral striatum, and premotor cortex) was linked with inhibition. Connectivity at θ frequencies was observed within this network of brain regions. Interestingly, greater connectivity between primary motor cortex (M1) and other motor regions was linked with greater impulsivity, whereas greater connectivity between M1 and inhibitory brain regions (OFC, ventral striatum) was linked with improved inhibition and diminished impulsivity. We observed similar patterns of activity on a parallel task in humans: low-frequency activity in sensorimotor cortex linked with action, θ activity in OFC/ventral prefrontal cortex (PFC) linked with inhibition. Thus, we show that δ and θ oscillations form distinct large-scale networks associated with action and inhibition, respectively. |
| Databáze: | OpenAIRE |
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