Serum adipokines in patients with psoriatic arthritis and psoriasis alone and their correlation with disease activity
| Autor: | Cheryl F. Rosen, Jai Jayakar, Lihi Eder, Dafna D. Gladman, Vinod Chandran, Fawnda Pellett, Arane Thavaneswaran, Remy A. Pollock |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Leptin Male medicine.medical_specialty Immunology Adipokine Arthritis Severity of Illness Index Gastroenterology General Biochemistry Genetics and Molecular Biology Psoriatic arthritis Insulin resistance Adipokines Rheumatology Risk Factors Internal medicine Psoriasis Humans Insulin Immunology and Allergy Medicine Metabolic Syndrome Adiponectin business.industry Arthritis Psoriatic Middle Aged medicine.disease Cross-Sectional Studies Endocrinology Antirheumatic Agents Female Insulin Resistance Metabolic syndrome business Biomarkers |
| Zdroj: | Annals of the Rheumatic Diseases. 72:1956-1961 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2012-202325 |
| Popis: | ObjectiveTo compare the prevalence of metabolic syndrome (MetS) and the levels of related biomarkers in patients with psoriatic arthritis (PsA) and psoriasis without arthritis (PsC).MethodsThis study compared patients with PsA and patients with PsC. The presence of MetS was determined. Serum levels of insulin, adiponectin and leptin were measured. The homeostasis model assessment for insulin resistance (HOMA-IR) was calculated. HOMA-IR, adiponectin and leptin were log-transformed. Continuous variables were compared using the t test and the χ2 test was used for discrete variables. Multivariate regression models were used to investigate the association of MetS and adiponectin with PsA compared to PsC after adjusting for potential confounding variables.Results203 PsA and 155 PsC patients were analysed. The prevalence of MetS was higher in PsA patients compared to those with PsC. However, this did not reach statistical significance (36.5% vs 27.1%, p=0.056). The levels of adipokines were significantly higher in PsA compared to PsC: adiponectin (8.8±5.2 vs 7.4±4.5 log (µg/ml), p=0.009) and leptin in women (3.1±0.8 vs 2.8±0.8, log (ng/ml), p=0.04). HOMA-IR was also higher in PsA (0.97±0.63 vs 0.68±0.81, pConclusionsMetS and related adipokines correlated with an increased burden of skin and joint inflammation. |
| Databáze: | OpenAIRE |
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