Limited expression of reticulocalbin-1 in lymphatic endothelial cells in lung tumor but not in normal lung
| Autor: | Shin-ichi Tsunoda, Hiromi Nabeshi, Kazuya Nagano, Tomoaki Yoshikawa, Yasunobu Yoshida, Haruhiko Kamada, Takuya Yamashita, Yasuhiro Abe, Yasuo Tsutsumi, Yasuo Yoshioka, Sunao Imai |
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| Rok vydání: | 2011 |
| Předmět: |
Lung Neoplasms
government.form_of_government Biophysics Biology Proteomics Biochemistry Cell Line Tumor medicine Humans Lung cancer Lung Molecular Biology Lymphatic Vessels Tissue microarray Calcium-Binding Proteins fungi Endothelial Cells Cell Biology medicine.disease Gene expression profiling Lymphatic Endothelium Tissue Array Analysis Cell culture Immunology Proteome Cancer research government sense organs Reticulocalbin 1 |
| Zdroj: | Biochemical and Biophysical Research Communications. 405:610-614 |
| ISSN: | 0006-291X |
| Popis: | Lymphatic endothelial cells in tumors (T-LECs) are considered to have different characteristics from LECs in non-tumor tissues (N-LECs). However, differences between the two types have not been well analyzed at molecular level. In this report, we performed differential proteome analysis of T-LEC and N-LEC models prepared by cultivation of LECs in tumor conditioned medium. By expression profiling of identified proteins using tissue microarrays, reticulocalbin-1 was found to be expressed in clinical specimen-derived T-LECs and lung cancer cells but not N-LECs. It is suggested that reticulocalbin-1 may be an important molecule in understanding T-LEC function and control of lymphatic metastasis. |
| Databáze: | OpenAIRE |
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