Acute Disseminated Intravascular Coagulation after Oxaliplatin Infusion
| Autor: | Jennifer R. Arthurs, Martin Gibbs, Sikander Ailawadhi, Mark R. Waddle, Eva Gupta, Nicole Gannon, Tanya S. Kakar, Myra A. Irvin, Deborah Fischer |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Drug medicine.medical_specialty Organoplatinum Compounds Colorectal cancer media_common.quotation_subject Leucovorin Gastroenterology 03 medical and health sciences 0302 clinical medicine Acute disseminated intravascular coagulation Recurrence Internal medicine Antineoplastic Combined Chemotherapy Protocols Drug Discovery Humans Medicine Pharmacology (medical) Aged media_common Pharmacology Disseminated intravascular coagulation business.industry General Medicine Disseminated Intravascular Coagulation medicine.disease Oxaliplatin Hypersensitivity reaction Regimen Infectious Diseases Oncology Creatinine Lymphatic Metastasis 030220 oncology & carcinogenesis Colonic Neoplasms Etiology 030211 gastroenterology & hepatology Fluorouracil business medicine.drug |
| Zdroj: | Chemotherapy. 62:295-300 |
| ISSN: | 1421-9794 0009-3157 |
| DOI: | 10.1159/000471844 |
| Popis: | Oxaliplatin is one of the most commonly used drugs for patients with colorectal cancer. It has rarely been associated with disseminated intravascular coagulation (DIC) with only 3 previously reported cases. In all those instances, the patients had started receiving oxaliplatin, developed evidence of DIC during the course of planned treatment, and recovered with supportive care. We report a case of a 71-year-old man with colorectal cancer treated successfully with an oxaliplatin-based regimen who had disease relapse after 3 years. When treated again with oxaliplatin, he developed signs of an acute hypersensitivity reaction, and eventually had signs and symptoms consistent with DIC despite appropriate management. This case is unique in that a DIC reaction evolving from a hypersensitivity reaction occurred after the patient had already tolerated the drug years earlier. It suggests a possible immune-mediated etiology to this rare occurrence that should be kept in mind while utilizing this commonly employed drug. |
| Databáze: | OpenAIRE |
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