Severe hypofibrinogenemia associated with bilateral ischemic necrosis of toes and fingers
| Autor: | Anne-Marie Fischer, O. Chafa, R. M. Hamladji, T. Chellali, A. Reghis, C. Sternberg |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
medicine.medical_specialty Necrosis medicine.medical_treatment Thrombin Time Ischemia Fibrinogen Amputation Surgical Fingers Surgical removal medicine Coagulopathy Ischemic necrosis Humans business.industry Thrombin Hematology General Medicine Hypofibrinogenemia Toes medicine.disease Afibrinogenemia Blood Coagulation Factors Surgery body regions Amputation Algeria Prothrombin Time Female Partial Thromboplastin Time medicine.symptom business medicine.drug |
| Zdroj: | Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 6(6) |
| ISSN: | 0957-5235 |
| Popis: | Severe hypofibrinogenemia was found in an Algerian woman who, since the age of 37 years, suffered three different episodes of ischemic necrosis of the toes and fingers leading to amputation of the toes and surgical removal of necrotic tissue (necretomy). No anti-fibrinogen antibody was present. The deficiency appeared to be due to severe congenital hypofibrinogenemia since the fibrinogen level remained at the same low level over a long period, without any abnormality of other coagulation proteins. The thrombotic events may be explained by the increased thrombin generation observed in the patient's plasma, due to the lack of thrombin adsorption onto a fibrin net. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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