Short Communication: Differences in 5-Year Survival After Cancer Diagnosis Between HIV Clinic Enrollees and the General U.S. Population
| Autor: | Geetanjali Chander, Richard D. Moore, Kala Visvanathan, Bryan Lau, Catherine R. Lesko, Anthony T Fojo, Corinne E. Joshu, Keri L. Calkins |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Time Factors Clinical cohort Epidemiology Immunology Human immunodeficiency virus (HIV) Antineoplastic Agents HIV Infections medicine.disease_cause Ambulatory Care Facilities Cohort Studies 03 medical and health sciences 0302 clinical medicine Virology Internal medicine Neoplasms medicine Humans 030212 general & internal medicine business.industry virus diseases Cancer Cancer survival Middle Aged medicine.disease Survival Analysis United States 030104 developmental biology Infectious Diseases Epidemiological Monitoring Female business U s population |
| Zdroj: | AIDS Res Hum Retroviruses |
| ISSN: | 1931-8405 |
| Popis: | A total of 236 people with HIV (PWH) with cancer diagnosed between 1997 and 2014 in the Johns Hopkins HIV Clinical Cohort (JHHCC) were compared with a sample from NCI's Surveillance, Epidemiology, and End Results (SEER) Program, presumed to be HIV negative. Using G-computation with random survival forest methods, we estimated 5-year restricted mean survival time (RMST) differences by HIV status. Sensitivity analyses were performed among non-AIDS defining cancers, males, females, and stratifying PWH by CD4 ≤ 200 or >200 cells/mm(3) at cancer diagnosis. PWH with CD4 ≤ 200 cells/mm(3) had decreased survival compared with those in SEER (−7 months; 95% CI = −13 to −2). Women with HIV and CD4 ≤ 200 cells/mm(3) at cancer diagnosis had lower survival than SEER women (−10 months; 95% CI = −18 to −2). In the total population, there was no significant difference in 5-year RMST; however, women with HIV and low CD4 had higher mortality despite accounting for stage at diagnosis and first course of cancer treatment. |
| Databáze: | OpenAIRE |
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