Effect of dehydroepiandrosterone on phosphatidylserine or phosphatidylcholine bilayers: DSC and X-ray diffraction study
| Autor: | N. Borochov, Ellen Wachtel, Diana Bach |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Lipid Bilayers
Biophysics Analytical chemistry Phosphatidylserines In Vitro Techniques Biochemistry Thermotropic crystal chemistry.chemical_compound Differential scanning calorimetry X-Ray Diffraction Phosphatidylcholine Dipalmitoyl phosphatidylcholine polycyclic compounds Phosphatidylserine Calorimetry Differential Scanning Chemistry Membranes Artificial Dehydroepiandrosterone Cell Biology Sterol Crystallography Membrane X-ray crystallography Phosphatidylcholines Thermodynamics Crystallite hormones hormone substitutes and hormone antagonists |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Biomembranes. 1463:162-166 |
| ISSN: | 0005-2736 |
| DOI: | 10.1016/s0005-2736(99)00193-5 |
| Popis: | The effect of dehydroepiandrosterone (DHEA) on the thermotropic and structural properties of phosphatidylserine or phosphatidylcholine membranes was investigated by differential scanning calorimetry and X-ray diffraction. At molar fractions of sterol, X (sterol), less than approximately 0.2, DHEA interacts with both types of model membranes, depressing the melting temperature and reducing the enthalpy of melting. At higher concentrations, phase separation of DHEA occurs with appearance of crystallites of the S2 monohydrate form. |
| Databáze: | OpenAIRE |
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