Dietary NaCl Regulates Renal Aminopeptidase N: Relevance to Hypertension in the Dahl Rat
| Autor: | Theressia L. Washington, Bryan P. Roxas, David L. Geenen, Mariam Farjah, Robert S. Danziger |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Brush border Sodium Angiotensin III Administration Oral chemistry.chemical_element CD13 Antigens Sodium Chloride Biology Kidney Rats Sprague-Dawley Angiotensin IV Internal medicine Renin–angiotensin system Internal Medicine medicine Animals RNA Messenger Rats Inbred Dahl Aminopeptidase N Chromosome Mapping Rats medicine.anatomical_structure Endocrinology chemistry Rats Inbred Lew Hypertension Proximal tubule hormones hormone substitutes and hormone antagonists |
| Zdroj: | Hypertension. 43:282-285 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.0000111584.15095.8a |
| Popis: | Aminopeptidase N (APN) is an abundant metallohydrolase in the brush border of kidney proximal tubule cells that degrades angiotensin III (Ang III) to angiotensin IV (Ang IV) and, along with dipeptidylaminopeptidase, degrades Ang IV. We examined the impact of a high-salt diet on renal APN activity and transcript abundance in the Sprague-Dawley and Dahl salt-sensitive (SS/Jr) rat strains. APN transcript abundance and protein abundance were ≈2-fold greater ( P |
| Databáze: | OpenAIRE |
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