Acute consumption of pecans decreases angiopoietin-like protein-3 in healthy males: a secondary analysis of randomized controlled trials
| Autor: | Alexis R. Marquardt, Chad M. Paton, Liana L Guarneiri, Jamie A. Cooper, Mai O. Spaulding |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult Male Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Juglans law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Animal science Sex Factors Randomized controlled trial Double-Blind Method law Angiopoietin-like Protein ANGPTL4 Reference Values Secondary analysis Medicine Humans Nuts Meals Triglycerides Angiopoietin-Like Protein 3 Carya Meal 030109 nutrition & dietetics Nutrition and Dietetics Cross-Over Studies business.industry digestive oral and skin physiology Fatty Acids Lipid Metabolism Postprandial Period Diet Postprandial Angiopoietin-like Proteins Area Under Curve Disease risk Female Fatty acid composition business |
| Zdroj: | Nutrition research (New York, N.Y.). 92 |
| ISSN: | 1879-0739 |
| Popis: | Angiopoietin-like proteins (ANGPTL)-3 and -4 regulate lipid metabolism, but the effect of tree nuts of varying fatty acid composition on post-meal responses is unknown. The purpose of the study was to conduct a secondary analysis of two studies on ANGPTL3 and -4 responses to meals containing different tree nuts. We hypothesized that the pecan-containing meal would mitigate postprandial rises in ANGPTL3 compared to the traditional meal without nuts in males, but not females. In addition, we hypothesized that there would be no other differences between any other treatments in ANGPTL3 or -4 responses. The two studies were double-blind, randomized crossover trials. Twenty-two adults (10=male, 12=female) completed study 1, which compared meals containing pecans vs. no nuts (control), and thirty adults (14=male, 16=female) completed study 2, which compared meals containing black walnuts, English walnuts (EW), or no nuts (control). Blood was collected at fasting, 30, 60, 120, and 180min postprandially. In study 1, ANGPTL3 was suppressed more in pecan vs. control in males (iAUC: -579.4±219.4 vs. -128.4±87.1pg/mL/3h, P |
| Databáze: | OpenAIRE |
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