Effects of Bisphenol S on hypothalamic neuropeptides regulating feeding behavior and apelin/APJ system in mice
Autor: | Anne Abot, Samir Aydi, Claude Knauf, Raja Rezg, Bessem Mornagui |
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Rok vydání: | 2018 |
Předmět: |
Male
0301 basic medicine medicine.medical_specialty Pro-Opiomelanocortin Health Toxicology and Mutagenesis media_common.quotation_subject Hypothalamus Neuropeptide Nerve Tissue Proteins 010501 environmental sciences Biology Weight Gain urologic and male genital diseases 01 natural sciences Eating Mice 03 medical and health sciences Phenols Internal medicine Orexigenic medicine Animals Obesity RNA Messenger Sulfones Benzhydryl Compounds Receptor 0105 earth and related environmental sciences Apelin receptor media_common Apelin Receptors Body Weight Neuropeptides Public Health Environmental and Occupational Health Appetite Feeding Behavior General Medicine Pollution Apelin 030104 developmental biology Endocrinology Endocrine disruptor hormones hormone substitutes and hormone antagonists medicine.drug |
Zdroj: | Ecotoxicology and Environmental Safety. 161:459-466 |
ISSN: | 0147-6513 |
Popis: | Since 2010, Bisphenol A (BPA), an endocrine disruptor has been restricted and replaced by analogues like Bisphenol S (BPS). However, little is known about BPS effects and growing concern have suspected the “BPA-free” Label. Several recent studies suggest that BPS is associated with increased risk of diabetes and obesity. However, the underlying mechanisms remain unidentified. The current study investigates investigate BPS effects on hypothalamic neuropeptides regulating feeding behavior, either orexigenic or anorexigenic in Swiss Albino mice. We also studied the effect of BPS on the apelinergic system (apelin/apelin receptor (APJ)) as an original physiological system with pleiotropic actions. Bisphenol S at 25, 50, 100 µg/kg was administered to mice in water drink for 10 weeks started after weaning. Our results showed that BPS exposure alters orexigenic hypothalamic neuropeptide (AgRP) regulating feeding behavior but not anorexigenic neuropeptides (POMC, CART). Such orexigenic alterations may underlay appetite disorders leading to a concomitant food intake and body weight gain increase. In addition, data show that BPS affects the hypothalamic apelinergic system. We found a significant decrease in APJ mRNA but not in apelin expression. Based on hypothalamic APJ distribution, we suggested a potent specific physiological alteration of this receptor in mediating neuroendocrine responses in hypothalamus. Thus, our findings provide that BPS exposure could contribute to the development of obesity and metabolic disorders. |
Databáze: | OpenAIRE |
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