Effects of Bisphenol S on hypothalamic neuropeptides regulating feeding behavior and apelin/APJ system in mice

Autor: Anne Abot, Samir Aydi, Claude Knauf, Raja Rezg, Bessem Mornagui
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
medicine.medical_specialty
Pro-Opiomelanocortin
Health
Toxicology and Mutagenesis
media_common.quotation_subject
Hypothalamus
Neuropeptide
Nerve Tissue Proteins
010501 environmental sciences
Biology
Weight Gain
urologic and male genital diseases
01 natural sciences
Eating
Mice
03 medical and health sciences
Phenols
Internal medicine
Orexigenic
medicine
Animals
Obesity
RNA
Messenger
Sulfones
Benzhydryl Compounds
Receptor
0105 earth and related environmental sciences
Apelin receptor
media_common
Apelin Receptors
Body Weight
Neuropeptides
Public Health
Environmental and Occupational Health
Appetite
Feeding Behavior
General Medicine
Pollution
Apelin
030104 developmental biology
Endocrinology
Endocrine disruptor
hormones
hormone substitutes
and hormone antagonists
medicine.drug
Zdroj: Ecotoxicology and Environmental Safety. 161:459-466
ISSN: 0147-6513
Popis: Since 2010, Bisphenol A (BPA), an endocrine disruptor has been restricted and replaced by analogues like Bisphenol S (BPS). However, little is known about BPS effects and growing concern have suspected the “BPA-free” Label. Several recent studies suggest that BPS is associated with increased risk of diabetes and obesity. However, the underlying mechanisms remain unidentified. The current study investigates investigate BPS effects on hypothalamic neuropeptides regulating feeding behavior, either orexigenic or anorexigenic in Swiss Albino mice. We also studied the effect of BPS on the apelinergic system (apelin/apelin receptor (APJ)) as an original physiological system with pleiotropic actions. Bisphenol S at 25, 50, 100 µg/kg was administered to mice in water drink for 10 weeks started after weaning. Our results showed that BPS exposure alters orexigenic hypothalamic neuropeptide (AgRP) regulating feeding behavior but not anorexigenic neuropeptides (POMC, CART). Such orexigenic alterations may underlay appetite disorders leading to a concomitant food intake and body weight gain increase. In addition, data show that BPS affects the hypothalamic apelinergic system. We found a significant decrease in APJ mRNA but not in apelin expression. Based on hypothalamic APJ distribution, we suggested a potent specific physiological alteration of this receptor in mediating neuroendocrine responses in hypothalamus. Thus, our findings provide that BPS exposure could contribute to the development of obesity and metabolic disorders.
Databáze: OpenAIRE
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