Melatonin Improves Levels of Zn and Cu in the Muscle of Diabetic Obese Rats
| Autor: | Diego Salagre, Pablo Olmedo, Marina Villalón-Mir, Ahmad Agil, Lorena Gaona, Fernando Gil-Hernández, Miguel Navarro-Alarcón, Juan Llopis, Mario Paredes, Pablo Alarcón-Guijo, Cristina Sánchez-González |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Antioxidant medicine.medical_treatment muscle and other organ and white adipose tissues Pharmaceutical Science Adipose tissue melatonin medicine.disease_cause Article Melatonin Pharmacy and materia medica Internal medicine Diabetes mellitus Diabetic obese rat medicine Extracellular Myocyte Chemistry zinc Skeletal muscle medicine.disease RS1-441 Zinc Endocrinology medicine.anatomical_structure copper diabetic obese rat Oxidative stress hormones hormone substitutes and hormone antagonists Copper medicine.drug |
| Zdroj: | Digibug. Repositorio Institucional de la Universidad de Granada instname Pharmaceutics, Vol 13, Iss 1535, p 1535 (2021) Pharmaceutics Volume 13 Issue 10 |
| DOI: | 10.3390/pharmaceutics13101535 |
| Popis: | Melatonin improves metabolic alterations associated with obesity and its diabetes (diabesity). We intend to determine whether this improvement is exerted by changing Zn and/or Cu tissue levels in liver, muscle, pancreas, and brain, and in internal (perirenal, perigonadal, and omentum) and subcutaneous lumbar white adipose tissues (IWAT and SWAT, respectively). Male Zücker diabetic fatty (ZDF) rats and lean littermates (ZL) were orally supplemented either with melatonin (10 mg/kg body weight/day) or vehicle for 6 weeks. Zn and Cu concentrations were not significantly influenced by diabesity in the analyzed tissues (p > 0.05), with the exception of Zn in liver. In skeletal muscle Zn and Cu, and in perirenal WAT, only Zn levels increased significantly with melatonin supplementation in ZDF rats (p < 0.05). This cytoplasmic Zn enhancement would be probably associated with the upregulation of several Zn influx membrane transporters (Zips) and could explain the amelioration in the glycaemia and insulinaemia by upregulating the Akt and downregulating the inhibitor PTP1B, in obese and diabetic conditions. Enhanced Zn and Cu levels in muscle cells could be related to the reported antioxidant melatonin activity exerted by increasing the Zn, Cu-SOD, and extracellular Cu-SOD activity. In conclusion, melatonin, by increasing the muscle levels of Zn and Cu, joined with our previously reported findings improves glycaemia, insulinaemia, and oxidative stress in this diabesity animal model. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|