MicroRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis
| Autor: | Lukas T. Jeker, Jeffrey A. Bluestone, Jonathan H. Esensten, Malika M. Morar, Wendy Rosenthal, Dimitri de Kouchkovsky |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
T-Lymphocytes Epitopes T-Lymphocyte Lymphocyte Activation T-Lymphocytes Regulatory Mice Epitopes 0302 clinical medicine T-Lymphocyte Subsets Immunology and Allergy Homeostasis Encephalomyelitis Cells Cultured Mice Knockout 0303 health sciences Antigen Presentation Cultured Bcl-2-Like Protein 11 Effector Experimental autoimmune encephalomyelitis CD28 hemic and immune systems Regulatory 3. Good health Interleukin-10 Interleukin 10 medicine.anatomical_structure RNA Long Noncoding Adult Heterozygote Encephalomyelitis Autoimmune Experimental Regulatory T cell Cells Knockout Antigen presentation Immunology chemical and pharmacologic phenomena Biology Article 03 medical and health sciences Experimental Young Adult Costimulatory and Inhibitory T-Cell Receptors CD28 Antigens Proto-Oncogene Proteins microRNA medicine Animals Humans Antigens 030304 developmental biology Autoimmune disease Histocompatibility Antigens Class II PTEN Phosphohydrolase Membrane Proteins medicine.disease Peptide Fragments MicroRNAs T-Lymphocyte Myelin-Oligodendrocyte Glycoprotein Apoptosis Regulatory Proteins Gene Deletion 030215 immunology Autoimmune |
| Zdroj: | De Kouchkovsky, D; Esensten, JH; Rosenthal, WL; Morar, MM; Bluestone, JA; & Jeker, LT. (2013). MicroRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis. Journal of Immunology, 191(4), 1594-1605. doi: 10.4049/jimmunol.1203567. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4076w7zf Journal of immunology (Baltimore, Md. : 1950), vol 191, iss 4 JOURNAL OF IMMUNOLOGY |
| Popis: | microRNAs (miRNA) are essential for regulatory T cell (Treg) function but little is known about the functional relevance of individual miRNA loci. We identified the miR-17–92 cluster as CD28 costimulation dependent, suggesting that it may be key for Treg development and function. Although overall immune homeostasis was maintained in mice with miR-17–92–deficient Tregs, expression of the miR-17–92 miRNA cluster was critical for Treg accumulation and function during an acute organ-specific autoimmune disease in vivo. Treg-specific loss of miR-17–92 expression resulted in exacerbated experimental autoimmune encephalitis and failure to establish clinical remission. Using peptide-MHC tetramers, we demonstrate that the miR-17–92 cluster was specifically required for the accumulation of activated Ag-specific Treg and for differentiation into IL-10–producing effector Treg. |
| Databáze: | OpenAIRE |
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