Conformational Memory of a Protein Revealed by Single-Molecule Spectroscopy
| Autor: | Jürgen Köhler, Richard J. Cogdell, Mario Schörner, June Southall, Sebastian R. Beyer |
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| Rok vydání: | 2015 |
| Předmět: |
Flexibility (engineering)
Protein function Chemistry Stochastic process Protein Conformation Supramolecular chemistry Light-Harvesting Protein Complexes food and beverages A protein Single Molecule Spectroscopy Surfaces Coatings and Films Crystallography Rhodopseudomonas Protein structure Spectrometry Fluorescence Materials Chemistry Biophysics Physical and Theoretical Chemistry |
| Zdroj: | The journal of physical chemistry. B. 119(44) |
| ISSN: | 1520-5207 |
| Popis: | Proteins are supramolecular machines that carry out a wide range of different functions, many of which require flexibility. Up until now spontaneous conformational fluctuations of proteins have always been assumed to reflect a stochastic random process. However, if changing between different conformational states was random, then it would be difficult to understand how conformational control of protein function could have evolved. Here we demonstrate that a single protein can show conformational memory. This is exactly the process that can facilitate the evolution of control of switching between two conformational states that can then be used to regulate protein function. |
| Databáze: | OpenAIRE |
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