Chest wall resection and reconstruction for locally recurrent breast cancer: From technical aspects to biological assessment
| Autor: | Mario Rietjens, Stefania Rizzo, Lorenzo Spaggiari, Francesco Petrella, Giulia Veronesi, Roberto Gasparri, Piergiorgio Solli, Davide Radice, Stefano Martella, Alessandro Borri, Domenico Galetta, Alessandro Pardolesi, Adele Tessitore, Monica Casiraghi |
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| Přispěvatelé: | Petrella F., Radice D., Borri A., Galetta D., Gasparri R., Casiraghi M., Tessitore A., Pardolesi A., Solli P., Veronesi G., Rizzo S., Martella S., Rietjens M., Spaggiari L., Petrella, F, Radice, D, Borri, A, Galetta, D, Gasparri, R, Casiraghi, M, Tessitore, A, Pardolesi, A, Solli, P, Veronesi, G, Rizzo, S, Martella, S, Rietjens, M, Spaggiari, L |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Reoperation medicine.medical_specialty Time Factors medicine.medical_treatment Breast Neoplasms Chest wall resection Disease-Free Survival Chest wall reconstruction Follow-Up Studie 03 medical and health sciences 0302 clinical medicine Breast cancer Retrospective Studie medicine Biomarkers Tumor Humans 030212 general & internal medicine Thoracoplasty Thoracic Wall Recurrent breast cancer Cancer death Mastectomy Aged Retrospective Studies Aged 80 and over business.industry Incidence (epidemiology) Incidence Middle Aged medicine.disease Surgery Survival Rate Italy 030220 oncology & carcinogenesis Female Radiology Neoplasm Recurrence Local business Developed country Breast Neoplasm Human Follow-Up Studies |
| Zdroj: | The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland. 14(1) |
| ISSN: | 1479-666X |
| Popis: | Introduction: Breast cancer is the leading cause of cancer death among women in the industrialized countries. The incidence of local recurrences after mastectomy and breast-conserving therapy varies between 5% and 40% depending on risk factors and primary therapy. Methods: From April 1999 to April 2011, 40 patients underwent chest wall resection and reconstruction for locally recurrent breast carcinoma with chest wall invasion. The main goal of surgery was local disease control to palliate clinical symptoms. Results: Local radical resection was achieved in 26 patients (65%). One, 2 and 5 year overall survival rates were 94.4%, 82.0% and 68.5%; 1, 2 and 5 year disease-free survival rates were 94.4%, 73.6% and 45.5% respectively.Univariate analysis indicated age (p = 0.002) and synchronous distant metastases (p = 0.020) as factors having a negative impact on overall survival; multivariate analysis disclosed age (p = 0.052) and synchronous metastases (p = 0.059) as factors with a slight negative impact on overall survival. Older age was associated with improved overall survival.Univariate analysis indicated synchronous distant metastases (p = 0.029) and the need of post resectional additional treatments (p = 0.022) as factors adversely conditioning disease-free survival or time to progression; multivariate analysis disclosed the need of post resectional additional treatments (p = 0.036) as the only factor adversely conditioning disease-free survival or time to progression. Conclusions: Chest wall resection and reconstruction for locally recurrent breast cancer is a feasible and safe procedure providing adequate local disease control and an excellent palliation of very disabling symptoms in a selected group of patients. |
| Databáze: | OpenAIRE |
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