Dl‑3‑n‑butylphthalide alleviates cognitive impairment in amyloid precursor protein/presenilin 1 transgenic mice by regulating the striatal‑enriched protein tyrosine phosphatase/ERK/cAMP‑response element‑binding protein signaling pathway

Autor:	Yan, Zhao, Wen-Qiang, Yang, Lu, Yu, Jing, Yang, Hai-Rong, Zhu, Lin, Zhang
Rok vydání:	2022
Předmět:	Cancer Research Immunology and Microbiology (miscellaneous) General Medicine
Zdroj:	Experimental and Therapeutic Medicine. 23
ISSN:	1792-1015 1792-0981
DOI:	10.3892/etm.2022.11248
Popis:	Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment and the deposition of amyloid plaques in the brain. In a transgenic mouse model of AD, cognitive impairment and synaptic dysfunction were revealed to be associated with soluble amyloid oligomers and to occur prior to plaque formation. The results of our previous studies revealed that striatal-enriched protein tyrosine phosphatase (STEP)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbbefaafe9615e1ad36eeb2e732e896 https://doi.org/10.3892/etm.2022.11248 Zobrazit plný text záznamu