Postbiotics of Lactobacillus casei target virulence and biofilm formation of Pseudomonas aeruginosa by modulating quorum sensing

Autor:	Somayeh Azami, Ehsan Arefian, Nasim Kashef
Rok vydání:	2021
Předmět:	Virulence Virulence Factors Quorum Sensing General Medicine Biochemistry Microbiology Lacticaseibacillus casei Mice Bacterial Proteins Biofilms Pseudomonas aeruginosa Genetics Animals Molecular Biology
Zdroj:	Archives of microbiology. 204(2)
ISSN:	1432-072X
Popis:	Among various anti-virulence aspects, the efficacy of the bioactive constituents of probiotics, referred to as postbiotics, to affect quorum sensing (QS)-modulated signaling of pathogens, is considered as a safe natural approach. The present study investigated the potential QS-inhibitory activity of lyophilized postbiotics from Lactobacillus casei sub sp. casei PTCC 1608 on virulence phenotypes and biofilm of two strains and three clinical isolates of Pseudomonas aeruginosa. The effect of L. casei postbiotics (LCP) at sub-minimum inhibitory concentration on the expression of QS genes including lasR/I, rhlR/I, pqsA, pqsR and virulence genes including pelF (pellicle/biofilm glycosyltransferase PelF), lasB (elastase LasB) and toxA (exotoxin A) was evaluated. The viability of mouse fibroblastic NIH/3T3 cell line treated with sub-MIC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bba9aeb9033a1f9299ed513406d4594 https://pubmed.ncbi.nlm.nih.gov/35106661 Zobrazit plný text záznamu Full text from SpringerLink