Chemoprophylactic and therapeutic efficacy of thymol in murine cystic echinococcosis
| Autor: | Guillermo Maria Denegri, Marina Alejandra Maggiore, María Celina Elissondo, Patricia Eugenia Pensel |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Farmacología y Farmacia
Pathology medicine.medical_specialty CIENCIAS MÉDICAS Y DE LA SALUD medicine.medical_treatment Pharmacology Albendazole Mice chemistry.chemical_compound Microscopy Electron Transmission Echinococcosis parasitic diseases medicine Animals Cystic Echinococcosis Dosing Echinococcus granulosus Thymol Anthelmintics Chemotherapy biology Cystic echinococcosis business.industry Essential Oils Therapeutic effect biology.organism_classification Echinococcus Granulosus Medicina Básica Infectious Diseases chemistry Toxicity Microscopy Electron Scanning Parasitology business medicine.drug |
| Zdroj: | Parasitology International. 64:435-440 |
| ISSN: | 1383-5769 |
| DOI: | 10.1016/j.parint.2015.06.005 |
| Popis: | Cystic echinococcosis is a zoonotic disease caused by the larval stage of the cestode Echinococcus granulosus. The drugs commonly used against cystic echinococcosis are benzimidazoles. Unfortunately, 20%-40% of cases do not respond favorably to such chemotherapy. Consequently, the search of new therapeutic alternatives such as the use of traditional medicinal plants has been increased. The aim of the current experimental work was to investigate the chemoprophylactic and clinical efficacy of thymol on mice infected with E. granulosus metacestodes. Thymol (40. mg/kg) was administered under two different therapeutic schemes: dosing every 24. h over 20. days and treatment every 12. h for 10. days. Thymol demonstrated efficacy against experimental murine cystic echinococcosis. The chemoprophylactic and therapeutic effects of thymol were comparable to that of albendazole. Due to the lack of toxicity observed in mice at the tested doses; we consider that thymol is a potential alternative to be applied for the treatment of human hydatid disease. Fil: Maggiore, Marina Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biología. Laboratorio de Zoonosis Parasitarias; Argentina Fil: Pensel, Patricia Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biología. Laboratorio de Zoonosis Parasitarias; Argentina Fil: Denegri, Guillermo Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biología. Laboratorio de Zoonosis Parasitarias; Argentina Fil: Elissondo, María Celina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Departamento de Biología. Laboratorio de Zoonosis Parasitarias; Argentina |
| Databáze: | OpenAIRE |
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