Atrial Natriuretic Peptide Concentration and Natriuretic Hormone Activity in Plasma of Patients with Chronic Renal Failure
| Autor: | Srámková J, J Lachmanová, Horký K, Jiří Widimský |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male Digoxin medicine.medical_specialty Erythrocytes Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Hemodynamics Biochemistry Endocrinology Atrial natriuretic peptide Renal Dialysis Internal medicine medicine Humans Na+/K+-ATPase business.industry Biochemistry (medical) Biological activity Blood Proteins General Medicine Saponins Natriuretic hormone Cardenolides Ultrafiltration (renal) Kidney Failure Chronic Chronic renal failure Female Natriuretic Agents Hemodialysis Sodium-Potassium-Exchanging ATPase business Atrial Natriuretic Factor |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-2007-1010923 |
| Popis: | To elucidate further the possible role of atrial natriuretic peptide (ANP) and hypothetical natriuretic hormone (NH) in volume and BP regulation in chronic renal failure (CRF) we measured plasma ANP, digitalis-like substances (DLS) and Na+-K+-ATPase activity (using 86Rb influx into RBC) in 9 patients with CRF before and after hemodialysis. Volume expansion between consecutive dialyses led in all patients to the elevation of plasma ANP (83.4 +/- 14.2 pmol/l) reaching in some overhydrated subjects and/or patients with concomitant cardiac insufficiency concentration greater than 150 pmol/l. Reduced 86Rb influx into RBC before hemodialysis (37.7 +/- 4.9% of controls) was accompanied by higher DLS concentrations (201 +/- 32 pmol/l). Ultrafiltration during hemodialysis with ECFV reduction lowered both ANP and DLS concentrations to 28.1 +/- 9.4 pmol/l and to 151 +/- 23 pmol/l, respectively, and abolished partly the inhibition of Na+-K+-ATPase activity (64.9 +/- 7.6% of controls). These changes corresponded to the degree of ECFV alteration. Our results suggest that both natriuretic principles are activated during ECFV expansion in CRF, probably as a corrective mechanism, with a tendency to normalize when ECFV is reduced during hemodialysis. |
| Databáze: | OpenAIRE |
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