Na+ deposition in the fibrotic skin of systemic sclerosis patients detected by 23Na-magnetic resonance imaging
| Autor: | Daniela Rosenhauer, Matthias Hammon, Kai-Uwe Eckardt, Alexander Cavallaro, Georg Schett, Christian Beyer, Jonathan Jantsch, Michael Uder, Dominik N. Müller, Anke Dahlmann, Jörg H W Distler, Friedrich C. Luft, Patrick Neubert, Jens Titze, Peter Linz, Christoph W. Kopp |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Skin score Pathology medicine.medical_specialty Systemic scleroderma Extracellular matrix Glycosaminoglycan 03 medical and health sciences 0302 clinical medicine Rheumatology Fibrosis medicine Humans Pharmacology (medical) skin and connective tissue diseases Skin 030203 arthritis & rheumatology Scleroderma Systemic integumentary system medicine.diagnostic_test business.industry Sodium Magnetic resonance imaging Clinical Science Control subjects medicine.disease Magnetic Resonance Imaging Forearm 030104 developmental biology Lower Extremity Case-Control Studies Biomarker (medicine) Female Sodium Isotopes Erratum business |
| Zdroj: | Rheumatology. 56:556-560 |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | Objective. Skin fibrosis is the predominant feature of SSc and arises from excessive extracellular matrix deposition. Glycosaminoglycans are macromolecules of the extracellular matrix, which facilitate Na(+) accumulation in the skin. We used (23)Na-MRI to quantify Na(+) in skin. We hypothesized that skin Na(+) might accumulate in SSc and might be a biomarker for skin fibrosis. Methods. In this observational case–control study, skin Na(+) was determined by (23)Na-MRI using a Na(+) volume coil in 12 patients with diffuse cutaneous SSc and in 21 control subjects. We assessed skin fibrosis by the modified Rodnan skin score prior to (23)Na-MRI and on follow-up 12 months later. Results. (23)Na-MRI demonstrated increased Na(+) in the fibrotic skin of SSc patients compared with skin from controls [mean (s.d.): 27.2 (5.6) vs 21.4 (5.3) mmol/l, P < 0.01]. Na(+) content was higher in fibrotic than in non-fibrotic SSc skin [26.2 (4.8) vs 19.2 (3.4) mmol/l, P < 0.01]. Furthermore, skin Na(+) amount was correlated with changes in follow-up modified Rodnan skin score (R(2) = 0.68). Conclusions. (23)Na-MRI detected increased Na(+) in the fibrotic SSc skin; high Na(+) content was associated with progressive skin disease. Our findings provide the first evidence that (23)Na-MRI might be a promising tool to assess skin Na(+) and thereby predict progression of skin fibrosis in SSc. |
| Databáze: | OpenAIRE |
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