Simvastatin improves wound strength after intestinal anastomosis in the rat
| Autor: | Oktay Irkorucu, Hatice Pasaoglu, Oge Tascilar, Kemal Karakaya, Mustafa Comert, Serefden Acikgoz, Canan Demirtas, G. Karadeniz Cakmak, Bulent Hamdi Ucan, Ali Ugur Emre, Handan Ankarali, Burak Bahadir, Gürkan Kertiş |
|---|---|
| Přispěvatelé: | Zonguldak Bülent Ecevit Üniversitesi |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Simvastatin Dehiscence Compressive Strength Anastomosis Gastroenterology Hydroxyproline chemistry.chemical_compound Random Allocation Reference Values Internal medicine medicine polycyclic compounds Animals Rats Wistar Bursting pressure Colectomy Analysis of Variance Wound Healing business.industry Anastomosis Surgical nutritional and metabolic diseases medicine.disease Immunohistochemistry Surgery Rats Intestines Stenosis Disease Models Animal chemistry Histopathology lipids (amino acids peptides and proteins) Collagen business Wound healing Anatomosis medicine.drug |
| Zdroj: | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 13(9) |
| ISSN: | 1873-4626 |
| Popis: | Annual Congress on Turkish National Surgery -- MAY, 2008 -- Antalya, TURKEY WOS: 000268575000024 PubMed: 19578821 Simvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor commonly known as a cholesterol-lowering drug with additional pleiotropic effects. Also, it is demonstrated that it prevents postoperative peritoneal adhesions in rat. This study was designed to assess its effects on the healing process of colonic anastomosis. Thirty-two male Wistar albino rats were randomized into two groups and subjected to colonic anastomosis. The study group was treated with simvastatin and the control group received only tap water instead. The rats were killed 3 and 7 days postoperatively. Wound complications, intra-abdominal abscesses, and anastomotic leaks and stenosis were recorded. Four types of assessment were performed: bursting pressure, hydroxyproline content, histopathology, and biochemical analysis. Compared to the control group, simvastatin-treated rats displayed a higher bursting pressure (p < 0.001) and anastomotic hydroxyproline content (p < 0.05). Simvastatin treatment leads to a significant decrease in malondealdehyde levels (p < 0.05) and increase in paraoxonase activity (p < 0.001) at both time points. Histopathological analysis revealed that simvastatin administration leads to a better anastomotic healing in terms of reepithelialization, decreased granuloma formation, reduced ischemic necrosis, and inflammatory infiltration to muscle layer. Clinically relevant doses of simvastatin do not have a negative impact on colonic anastomosis but improve intestinal wound healing in rats. |
| Databáze: | OpenAIRE |
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