Clinical study of different doses of atorvastatin combined with febuxostat in patients with gout and carotid atherosclerosis
| Autor: | Feng-ju Wei, Ming-Hua Xu, Li-na Shang, Zheng Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Carotid atherosclerosis
medicine.medical_specialty Gout business.industry Incidence (epidemiology) Atorvastatin General Medicine medicine.disease Gastroenterology Clinical study chemistry.chemical_compound Febuxostat chemistry Internal medicine Medicine Uric acid Original Article In patient business medicine.drug |
| Zdroj: | Pakistan Journal of Medical Sciences |
| ISSN: | 1681-715X 1682-024X |
| DOI: | 10.12669/pjms.36.6.2945 |
| Popis: | Objective: To evaluate the efficacy of atorvastatin combined with febuxostat in the treatment of gout patients with carotid atherosclerosis and to observe the effects on serum tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and C-reactive protein (CRP) levels, carotid plaques, and the adverse reactions. Methods: Seventy patients with gout and carotid atherosclerosis admitted to Affiliated Hospital of Hebei University from January 2014 to June 2017 were randomly divided into a treatment group and a control group. The treatment group received oral febuxostat 40 mg/day combined with atorvastatin 40 mg/day. The control group was given 40 mg/day febuxostat combined with 20 mg/day atorvastatin for 90 days. The effects of treatment on TNF-α, IL-1β, and CRP levels and carotid plaques of the patients were observed. Results: After 90 days of treatment, serum TNF-α, IL-1β, and CRP levels, as well as HUA and total cholesterol (TC), decreased in both groups after treatment. There were significant differences observed (p < 0.05). The carotid artery plaques in the two groups were significantly smaller after treatment (P 0.05). Conclusion: Double doses of atorvastatin combined with febuxostat can effectively reduce uric acid to improve the inflammatory state in patients and reduce carotid plaques without increasing the incidence of adverse reactions. doi: https://doi.org/10.12669/pjms.36.6.2945 How to cite this:Zhang Z, Xu MH, Wei FJ, Shang LN. Clinical study of different doses of atorvastatin combined with febuxostat in patients with gout and carotid atherosclerosis. Pak J Med Sci. 2020;36(6):1334-1338. doi: https://doi.org/10.12669/pjms.36.6.2945 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Databáze: | OpenAIRE |
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