In vitro effect of thymosin alpha 1 on the expression of peanut agglutinin binding by murine thymocytes
| Autor: | Luigi Frati, Cristina Rinaldi-Garaci, Anna Maria Baldassarre, Antonella Pesce, J. Lazdins |
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| Rok vydání: | 1986 |
| Předmět: |
Peanut agglutinin
Thymalfasin T-Lymphocytes Immunology Biology Leukocyte Count Mice Peanut Agglutinin Lectins Animals Binding site Receptor musculoskeletal neural and ocular physiology Ligand (biochemistry) Molecular biology Phenotype In vitro Mice Inbred C57BL Thymosin Receptors Mitogen biological sciences cardiovascular system biology.protein tissues hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Cellular immunology. 101(1) |
| ISSN: | 0008-8749 |
| Popis: | Thymosin alpha 1 induces the loss of PNA binding ability by subpopulation of thymic cells. This loss is probably due to an endocytic process. Nevertheless this disappearance is not a permanent one, suggesting a recycling of the PNA binding molecule. The cells that modulate their PNA binding sites after exposure to Thymosin alpha 1 are a small proportion of the total PNA+ thymocytes, indicating that not all thymocytes are susceptible to the thymic hormone Thymosin alpha 1. Conversely the exposure of thymocytes to Thymosin alpha 1 induces the disappearance of the binding sites for this ligand without further recycling, behavior expected for the receptor of a regulatory ligand. These results also indicate that the Thymosin alpha 1 and the PNA binding sites are on different molecules on the surface of the PNA+ thymocytes. |
| Databáze: | OpenAIRE |
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