The prevalence of VKORC1 1639 GA and CYP2C9*2*3 genotypes in patients that requiring anticoagulant therapy in Turkish population
| Autor: | Secil Akdur, Hakki Engin Aksulu, Fatma Silan, Buket Gungor, Ahmet Uludag, Öztürk Özdemir, Halil Fatih Asgun, Sinem Atik, Semra Ozdemir, Fatma Mutlu Kukulguven, Coskun Silan, Omer Tamer Dogan |
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| Přispěvatelé: | [Silan, Coskun -- Uludag, Ahmet -- Atik, Sinem -- Ozdemir, Ozturk] Canakkale Onsekiz Mart Univ, Fac Med, Dept Med Genet, TR-17100 Canakkale, Turkey -- [Silan, Coskun -- Gungor, Buket -- Akdur, Secil -- Aksulu, Hakki Engin] Canakkale Onsekiz Mart Univ, Dept Pharmacol, Fac Med, TR-17100 Canakkale, Turkey -- [Dogan, Omer Tamer] Cumhuriyet Univ, Fac Med, Dept Chest, TR-58140 Sivas, Turkey -- [Kukulguven, Fatma Mutlu] Cumhuriyet Univ, Dept Emergency, Fac Med, TR-58140 Sivas, Turkey -- [Asgun, Halil Fatih] Canakkale Onsekiz Mart Univ, Fac Med, Dept Cardiovasc Surg, TR-17100 Canakkale, Turkey -- [Ozdemir, Ozturk] Canakkale Onsekiz Mart Univ, Fac Med, Dept Nucl Med, TR-17100 Canakkale, Turkey -- [Ozdemir, Ozturk] Cumhuriyet Univ, Dept Med Genet, Fac Med, TR-58140 Sivas, Turkey, Asgun, H. Fatih -- 0000-0002-8969-5886, kukul guven, fatma mutlu -- 0000-0003-3755-6021 |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Turkish population medicine.medical_specialty Genotype Turkey Deep vein Gastroenterology Polymorphism Single Nucleotide VKORC1 1639 G < A Mixed Function Oxygenases Gene Frequency Internal medicine Vitamin K Epoxide Reductases Genetics medicine Prevalence Humans Allele Anticoagulant therapy Molecular Biology Allele frequency Alleles Aged Cytochrome P-450 CYP2C9 Aged 80 and over business.industry Anticoagulants General Medicine Middle Aged medicine.disease Thrombosis CYP2C9*2 and*3 SNP medicine.anatomical_structure Cohort Female VKORC1 Aryl Hydrocarbon Hydroxylases business Follow-Up Studies |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1573-4978 2306-5265 |
| Popis: | WOS: 000310586700120 PubMed ID: 23065265 The aim was to investigate the prevalence of VKORC1 and CYP2C9 genotypes in patients requiring anticoagulant therapy in two different region's populations of Turkey. The recent cohort included 292 patients that needed anticoagulant therapy, and who had a history of deep vein thrombosis and/or pulmonary artery thromboembolism. Genomic DNA was isolated from peripheral blood samples and the StripAssay reverse hybridization or Real Time PCR technique was used for genotype analysis. Genotypes for CYP2C9 were detected as follows: 165 (56.5 %) for CYP2C9*1/*1, 67 (23.0 %) for CYP2C9*1/*2, 25 (8.6 %) for CYP2C9*1/*3, 9 (3.0 %) for CYP2C9*2/*2, 21 (7.2 %) for CYP2C9*2/*3, 5(1.7 %) for CYP2C9*3/*3 for CYP2C9 and the allele frequencies were: 0.723 for allele*1, 0.182 for allele*2 and 0.095 for allele*3 respectively. Genotypes for VKORC1 were detected as follows: 64 (21.9 %) for GG, 220 (75.4 %) for GA and 8 (2.7 %) for AA alleles. The G allele frequency was detected as 0.596, and the A allele frequency was 0.404. The VKORC1 1639 G > A and CYP2C9 mutation prevalence and allele frequency of the current results from two different populations (Sivas and Canakkale) showed similarly very variable profiles when compared to the other results from the Turkish population. |
| Databáze: | OpenAIRE |
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