Inhibition of pressor effects of angiotensin I and augmentation of depressor effects of bradykinin by synthetic peptides
| Autor: | S. L. Engel, B. I. Gold, T. R. Schaeffer, Bernard Rubin |
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| Rok vydání: | 1972 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Bradykinin Venom Blood Pressure General Biochemistry Genetics and Molecular Biology stat chemistry.chemical_compound Internal medicine Renin–angiotensin system medicine Potency Animals chemistry.chemical_classification Teprotide Angiotensin II Drug Synergism Rats Inbred Strains Rats Enzyme Endocrinology chemistry Peptides |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 140(1) |
| ISSN: | 0037-9727 |
| Popis: | SummarySeven synthetic peptides that correspond to compounds found in the venom of Bothrops jararaca were studied in normo-tensive, urethanized rats infused with pen-tolinium. When administered stat iv, the peptides inhibited pressor responses induced by angiotensin I but not those induced by angiotensin II. This activity was most likely the result of inhibition of angiotensin-converting enzyme. The peptides appeared to differ from each other with respect to potency and duration of action. The 3 test peptides injected im and sc displayed rapid, effective absorption by those routes.Three peptides tested stat iv in normoten-sive; urethanized rats augmented the vasodepressor effect of bradykinin to different degrees. |
| Databáze: | OpenAIRE |
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