Vitamin D deficiency in systemic lupus erythematosus: prevalence, predictors and clinical consequences
| Autor: | Nerea Olivares, Maria-Victoria Egurbide, Guillermo Ruiz-Irastorza, Ciriaco Aguirre, Agustin Martinez-Berriotxoa |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Calcitriol Severity of Illness Index vitamin D deficiency chemistry.chemical_compound Sex Factors Rheumatology Risk Factors Internal medicine Severity of illness medicine Vitamin D and neurology Humans Lupus Erythematosus Systemic Pharmacology (medical) skin and connective tissue diseases Fatigue Calcifediol Lupus erythematosus business.industry Age Factors Odds ratio Middle Aged Prognosis Vitamin D Deficiency medicine.disease Connective tissue disease Cross-Sectional Studies Endocrinology chemistry Antirheumatic Agents Female business Cholecalciferol Hydroxychloroquine medicine.drug |
| Zdroj: | Rheumatology. 47:920-923 |
| ISSN: | 1462-0332 1462-0324 |
| DOI: | 10.1093/rheumatology/ken121 |
| Popis: | Objectives. We aimed to establish the prevalence, predictors and clinical consequences of vitamin D deficiency in patients with SLE. Methods. Cross-sectional study including patients fulfilling ACR criteria for the classification of SLE. Serum 25(OH)D levels at 30 and 10 ng/ml were the cut-off values for vitamin D insufficiency and vitamin D deficiency, respectively. SLE activity was measured by SLEDAI and irreversible organ damage by the SLICC-ACR index. Fatigue was quantified using a 0–10 visual analogue scale (VAS). Results. Ninety-two patients (90% women, 98% white) were included in the study. Sixty-nine (75%) and 14 (15%) patients presented with vitamin D insufficiency and deficiency, respectively. Female sex (P ¼ 0.001), treatment with HCQ (P ¼ 0.014) and treatment with calcium and vitamin D (P ¼ 0.049) predicted higher levels of 25(OH)D. Photosensitivity [odds ratio (OR) 3.5] and photoprotection (OR 5.7) predicted vitamin D insufficiency and deficiency, respectively. Higher age (OR 0.95) and HCQ use (OR 0.29) protected against vitamin D deficiency. Patients with vitamin D deficiency had a higher degree of fatigue as quantified by a 0–10 VAS (mean 5.32 vs 4.03, P ¼ 0.08). No relation was seen between vitamin D insufficiency or deficiency and disease duration, SLEDAI or SLICC-ACR indexes. Conclusions. Vitamin D insufficiency and deficiency are common in patients with SLE and are associated with sun avoidance. HCQ prevented vitamin D deficiency. Vitamin D deficiency was related to a higher degree of fatigue. Vitamin D levels had no relation with SLE severity. |
| Databáze: | OpenAIRE |
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