Plasma 2-arachidonoylglycerol is a biomarker of age and menopause related insulin resistance and dyslipidemia in lean but not in obese men and women

Autor: Uberto Pagotto, Flaminia Fanelli, Antonio Maria Morselli-Labate, Marianna Mastroroberto, Alessandra Gambineri, Valentina Vicennati, Renato Pasquali, Daniela Ibarra Gasparini, Margherita Baccini, Ilaria Belluomo, Marco Mezzullo, Elena Casadio, Valentina D. Di Lallo
Přispěvatelé: Fanelli, Flaminia, Mezzullo, Marco, Belluomo, Ilaria, Di Lallo, Valentina Diana, Baccini, Margherita, Ibarra Gasparini, Daniela, Casadio, Elena, Mastroroberto, Marianna, Vicennati, Valentina, Gambineri, Alessandra, Morselli-Labate, Antonio Maria, Pasquali, Renato, Pagotto, Uberto
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Aging
BMI
body mass index
Overweight
0302 clinical medicine
LC-MS/MS
liquid chromatography-tandem mass spectrometry
2. Zero hunger
Aged
80 and over
Int
interaction
OB
obese
Middle Aged
EC
endocannabinoid
3. Good health
Menopause
HOMA-IR
homeostatic model assessment of insulin resistance
2-Arachidonoylglycerol
Biomarker (medicine)
lipids (amino acids
peptides
and proteins)
Original Article
Female
medicine.symptom
2AG
2-arachidonoylglycerol
Adult
lcsh:Internal medicine
medicine.medical_specialty
Endocannabinoid system
DBP
diastolic blood pressure
030209 endocrinology & metabolism
Arachidonic Acids
OW
overweight
Dysmetabolism
Glycerides
03 medical and health sciences
Insulin resistance
Internal medicine
medicine
Humans
1AG
1-arachidonoylglycerol
Obesity
lcsh:RC31-1245
Molecular Biology
Aged
Dyslipidemias
NW
normal weight
business.industry
SBP
systolic blood pressure
nutritional and metabolic diseases
Cell Biology
Anthropometry
medicine.disease
HDL
high density lipoprotein
030104 developmental biology
Endocrinology
Insulin Resistance
business
SD
standard deviation
Body mass index
Dyslipidemia
Biomarkers
ECS
endocannabinoid system
Endocannabinoids
Zdroj: Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 5, Pp 406-415 (2017)
ISSN: 2212-8778
Popis: Objective The endocannabinoid system hypertonicity features obesity. Excess circulating 2-arachidonoylglycerol was variously associated with obesity-related metabolic impairment; however, unstandardized experimental and analytical settings have clouded its usefulness as a dysmetabolism biomarker. We aimed at assessing the influence of body mass index (BMI), menopause in women, and aging in men on 2-arachidonoylglycerol relationship with metabolic parameters. Methods Adult, unmedicated women (premenopausal (preMW): n = 103; menopausal (MW): n = 81) and men (n = 144) were stratified in normal weight (NW; BMI: 18.5–24.9 kg/m2), overweight (OW; BMI: 25.0–29.9 kg/m2), and obese (OB; BMI ≥ 30.0 kg/m2) classes. Anthropometric and metabolic parameters were determined. Plasma 2-arachidonoylglycerol was measured by a validated liquid chromatography-mass spectrometry assay. Results 2-arachidonoylglycerol level was raised by menopause (P
Highlights • Plasma 2AG is a biomarker of dysmetabolism rather than obesity. • Menopause is a major determinant of plasma 2AG levels in females. • Increased plasma 2AG level features obese premenopausal females and obese males. • 2AG is a biomarker of dyslipidemia and insulin resistance in lean menopausal women. • 2AG is a biomarker of dyslipidemia and age-related insulin resistance in lean men.
Databáze: OpenAIRE
Externí odkaz: