Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
| Autor: | Taku Sato, Hiroyuki Tada, Kazuto Ishida, Hiroyuki Tezuka, Toshiaki Ohteki, Seiichi Kuwajima |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
CpG Oligodeoxynucleotide
Recombinant Fusion Proteins Immunology CD40 Ligand Mice Transgenic Cell Communication medicine.disease_cause Interferon-gamma Mice Immune system Listeria monocytogenes Animals Congenic T-Lymphocyte Subsets medicine Immunology and Allergy Animals Humans Listeriosis CD40 Antigens Cells Cultured Interleukin-15 CD40 biology Chemistry Lethal dose hemic and immune systems Dendritic Cells Interleukin-12 CD11c Antigen Mice Inbred C57BL Crosstalk (biology) CpG site Gene Expression Regulation Interleukin 15 Radiation Chimera biology.protein CpG Islands Immunologic Memory |
| Zdroj: | Nature immunology. 7(7) |
| ISSN: | 1529-2908 |
| Popis: | The function of interleukin 15 (IL-15) in unmethylated CpG oligodeoxynucleotide (CpG)–induced immune responses remains unknown. Here, in response to CpG, both wild-type and natural killer cell–depleted mice produced IL-12 and became resistant to a lethal dose of Listeria monocytogenes. In contrast, CpG-treated IL-15-deficient mice produced little IL-12 and succumbed to L. monocytogenes. CpG-stimulated conventional dendritic cells (cDCs) were the main producers of both IL-15 and IL-12, but cDCs did not produce IL-12 in the absence of plasmacytoid DCs (pDCs). The cDC-derived IL-15 induced CD40 expression by cDCs. Interaction between CD40 on cDCs and CD40 ligand on pDCs led to IL-12 production by cDCs. Thus, IL-15-dependent crosstalk between cDCs and pDCs is essential for CpG-induced immune activation. |
| Databáze: | OpenAIRE |
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