Improved synthesis of DCDHF fluorophores with maleimide functional groups

Autor:	Zhikuan Lu, Robert J. Twieg, Ryan L. Weber
Rok vydání:	2006
Předmět:	chemistry.chemical_compound chemistry Furan Organic Chemistry Drug Discovery Nucleophilic substitution Amine gas treating Mitsunobu reaction Biochemistry Combinatorial chemistry Maleimide Article
Zdroj:	Tetrahedron Letters. 47:7213-7217
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2006.07.142
Popis:	A group of dicyanodihydrofuran (DCDHF) fluorophores with thiol-reactive maleimide functionality has been synthesized. One of the methods involves aromatic nucleophilic substitution reaction between an arylfluoride containing DCDHF and an amine containing protected maleimide. An alternative and generally useful method involves combination of the Mitsunobu reaction of a DCDHF-OH with a furan or 2-methylfuran protected maleimide and then subsequent retro Diels–Alder reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ba756f4330b361b6415d1f0e481efb4 https://doi.org/10.1016/j.tetlet.2006.07.142 Zobrazit plný text záznamu Full Text from ScienceDirect