Self-Assembly of Phosphate Amphiphiles in Mixtures of Prebiotically Plausible Surfactants
| Autor: | Colm D. Duffy, Anders N. Albertsen, Pierre-Alain Monnard, John D. Sutherland |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Photobleaching
Aqueous solution Chemistry Bilayer Vesicle Alkyl phosphate Hydrogen-Ion Concentration Fluoresceins Phosphate Agricultural and Biological Sciences (miscellaneous) Organophosphates Permeability Phosphates Surface-Active Agents chemistry.chemical_compound Membrane Chemical engineering Space and Planetary Science Amphiphile Organic chemistry Self-assembly Unilamellar Liposomes Research Articles |
| Zdroj: | Albertsen, A N, Duffy, C D, Sutherland, J D & Monnard, P-A 2014, ' Self-assembly of phosphate amphiphiles in mixtures of prebiotically plausible surfactants ', Astrobiology, vol. 14, pp. 462-472 . https://doi.org/10.1089/ast.2013.1111 |
| ISSN: | 1557-8070 1531-1074 |
| DOI: | 10.1089/ast.2013.1111 |
| Popis: | The spontaneous formation of closed bilayer structures from prebiotically plausible amphiphiles is an essential requirement for the emergence of early cells on prebiotic Earth. The sources of amphiphiles could have been both endo- and exogenous (accretion of meteorite carbonaceous material or interstellar dust particles). Among all prebiotic possible amphiphile candidates, those containing phosphate are the least investigated species because their self-assembly occurs in a seemingly too narrow range of conditions. The self-assembly of simple phosphate amphiphiles should, however, be of great interest, as contemporary membranes predominantly contain phospholipids. In contrast to common expectations, we show that these amphiphiles can be easily synthesized under prebiotically plausible environmental conditions and can efficiently form bilayer structures in the presence of various co-surfactants across a large range of pH values. Vesiculation was even observed in crude reaction mixtures that contained 1-decanol as the amphiphile precursor. The two best co-surfactants promoted vesicle formation over the entire pH range in aqueous solutions. Expanding the pH range where bilayer membranes self-assemble and remain intact is a prerequisite for the emergence of early cell-like compartments and their preservation under fluctuating environmental conditions. These mixed bilayers also retained small charged solutes, such as dyes. These results demonstrate that alkyl phosphate amphiphiles might have played a significant role as early compartment building blocks. Key Words: Vesicles—Alkyl phosphate—Prebiotic synthesis—Amphiphile mixtures. Astrobiology 14, 462–472. |
| Databáze: | OpenAIRE |
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