Plasma Levels of Vitamin E in Pregnant Women prior to the Development of Preeclampsia and Other Hypertensive Complications
| Autor: | Boris Kaplan, Avi Ben-Haroush, Raoul Orvieto, Moshe Hod, Ron Bardin, Daniella Harell, Jacob Bar |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Pregnancy Complications Cardiovascular medicine.disease_cause Preeclampsia Pathogenesis Pre-Eclampsia Pregnancy Internal medicine Blood plasma Humans Vitamin E Medicine Prospective Studies reproductive and urinary physiology Vitamine e business.industry fungi food and beverages Obstetrics and Gynecology Plasma levels medicine.disease female genital diseases and pregnancy complications Endocrinology Reproductive Medicine Hypertension Regression Analysis Female business Oxidative stress |
| Zdroj: | Gynecologic and Obstetric Investigation. 54:26-30 |
| ISSN: | 1423-002X 0378-7346 |
| Popis: | Our aim was to investigate whether decreased levels of vitamin E can be measured during the early stages of pregnancy in women at risk of developing preeclampsia or other associated complications before the onset of the clinical syndrome. We prospectively measured the plasma concentrations of vitamin E in 62 pregnant women at 7–32 weeks of gestation who were at risk of developing preeclampsia and other complications, before the appearance of clinical signs. The results were compared with those of 16 healthy controls. Of the 62 study patients, 8 (13%) developed preeclampsia, and 18 (29%) had other complications, such as intrauterine growth restriction (n = 8), fetal or neonatal loss (n = 9), and preterm delivery (≤30 weeks of gestation; n = 7). Both gestational age at delivery and birth weight were significantly lower in the patients with complications than in the healthy controls. However, there were no significant differences in vitamin E levels between women who developed preeclampsia or other complications and those who did not. There was no significant correlation between plasma vitamin E and creatinine concentrations. A significant positive correlation was found in both the complicated and normal pregnancies between plasma vitamin E concentration and gestational week of blood collection (R = 0.485, p < 0.001, and R = 0.718, p = 0.004, respectively). We conclude that the vitamin E concentrations are not decreased prior to the development of preeclampsia or other complications in women at risk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|