An overview of the insulin signaling pathway in model organisms Drosophila melanogaster and Caenorhabditis elegans
| Autor: | Sanaz G. Biglou, William G. Bendena, Ian D. Chin-Sang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Physiology
medicine.medical_treatment ved/biology.organism_classification_rank.species Biology Biochemistry 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Endocrinology Antigens CD medicine Animals Drosophila Proteins Humans Insulin Caenorhabditis elegans Caenorhabditis elegans Proteins Model organism 030304 developmental biology 0303 health sciences ved/biology Growth factor Neuropeptides PTEN Phosphohydrolase Metabolism biology.organism_classification Receptor Insulin Cell biology Insulin receptor Drosophila melanogaster biology.protein Signal transduction 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Peptides. 145:170640 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/j.peptides.2021.170640 |
| Popis: | The insulin/insulin-like growth factor signaling pathway is an evolutionary conserved pathway across metazoans and is required for development, metabolism and behavior. This pathway is associated with various human metabolic disorders and cancers. Thus, model organisms including Drosophila melanogaster and Caenorhabditis elegans provide excellent opportunities to examine the structure and function of this pathway and its influence on cellular metabolism and proliferation. In this review, we will provide an overview of human insulin and the human insulin signaling pathway and explore the recent discoveries in model organisms Drosophila melanogaster and Caenorhabditis elegans. Our review will provide information regarding the various insulin-like peptides in model organisms as well as the conserved functions of insulin signaling pathways. Further investigation of the insulin signaling pathway in model organisms could provide a promising opportunity to develop novel therapies for various metabolic disorders and insulin-mediated cancers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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