The hemagglutinin of Staphylococcus saprophyticus is a major adhesin for uroepithelial cells
| Autor: | U. Wengler-Becker, S. G. Gatermann, H.-G. W. Meyer |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Staphylococcus
Immunology Biology medicine.disease_cause Microbiology Bacterial Adhesion Epithelium medicine Animals Humans Antiserum chemistry.chemical_classification Staphylococcus saprophyticus Sheep Binding protein Erythrocyte Membrane Hemagglutinin biology.organism_classification Fibronectins Bacterial adhesin Infectious Diseases Hemagglutinins chemistry Parasitology Ureter Glycoprotein Bacteria Research Article |
| Zdroj: | Infection and immunity. 64(9) |
| ISSN: | 0019-9567 |
| Popis: | The 160-kDa hemagglutinin of Staphylococcus saprophyticus also serves as a fibronectin-binding protein, and the two activities may be present on different parts of the molecule. Bacteria expressing the 160-kDa hemagglutinin bound in large numbers to histological sections of human ureters, whereas nonhemagglutinating bacteria did not bind. Binding was decreased by an antiserum to the 160-kDa protein and by a preparation of sheep erythrocyte membranes. Fibronectin had no effect. We therefore conclude that binding of S. saprophyticus to uroepithelial cells is mediated by the hemagglutinating activity of the 160-kDa surface protein. |
| Databáze: | OpenAIRE |
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