Differing calcium requirements for regulatory effects of ATP, ATPγS and adenosine on O2• responses of human neutrophils
| Autor: | Kent J. Johnson, T. W. Cunningham, Peter A. Ward, Blair A.M. Walker |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adenosine
Neutrophils Neutrophile Biophysics chemistry.chemical_element Stimulation Peptide Biology Calcium Inhibitory postsynaptic potential Biochemistry Adenosine Triphosphate Superoxides medicine Extracellular Humans Molecular Biology chemistry.chemical_classification Cell Biology Cell biology N-Formylmethionine Leucyl-Phenylalanine chemistry Signal transduction medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 154:746-751 |
| ISSN: | 0006-291X |
| Popis: | In formyl peptide stimulated human neutrophils the enhancement of O2 • responses by ATP and ATPγS requires extracellular calcium. In contrast, the inhibitory effects of adenosine are independent of a calcium requirement. Rates of O2 • generation are not affected by these adenine compounds. Rather, ATP and ATPγS cause a sustained period of generation whereas adenosine causes an abrupt early termination of the O2 • response. The differing calcium requirements for regulatory effects of adenine compounds on O2 • responses of stimulated neutrophils suggests that ATP (or ATPγS) and adenosine may exert their effects at different points in the pathway of signal transduction events. |
| Databáze: | OpenAIRE |
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