Simultaneous subconjunctival and subscleral mitomycin-C application in trabeculectomy
| Autor: | Mohamed Khalil, Magdi Helal, Mohamed Hisham, Fathi El Sayyad, Hazem El-Hamzawey, Mohamed Belmekki |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Intraocular pressure Visual acuity Randomization genetic structures medicine.medical_treatment Eye disease Mitomycin Trabeculectomy law.invention Randomized controlled trial law Ophthalmology medicine Humans Prospective Studies Intraocular Pressure Aged Aged 80 and over Chemotherapy Antibiotics Antineoplastic business.industry Mitomycin C Glaucoma Middle Aged medicine.disease Combined Modality Therapy eye diseases Surgery Treatment Outcome Female sense organs medicine.symptom Safety business Conjunctiva Sclera |
| Zdroj: | Ophthalmology. 107(2) |
| ISSN: | 0161-6420 |
| Popis: | Objective To establish the efficacy and safety of simultaneous subconjunctival and subscleral application of mitomycin-C in trabeculectomy. Design A prospective, randomized study. Participants Sixty-eight patients (68 eyes) with refractory glaucomas were included in the study. Intervention Eyes were randomly assigned to receive intraoperative mitomycin-C (0.3 mg/ml) applied under the conjunctival flap (group 1), scleral flap (group 2), or under both flaps (group 3). Main outcome measures Mean intraocular pressure (IOP), postoperative medications, visual acuity, filtering bleb appearance, and complications. Results There was a significant difference in IOP at 6, 9, and 12 months after surgery among the three groups ( P = 0.021, 0.026, and 0.033, respectively ANOVA). At 12 months, the mean IOP in group 3 was 9.8 ± 3.7 mmHg compared with 13.4 ± 5.5 mmHg in group 2. ( P = 0.015) and 12.4 ± 4.4 mmHg in group 1 ( P = 0.039). Success rate (21 mmHg or less), number of antiglaucoma medications, and complications showed no statistical significant difference between the three groups at each postoperative visit. Conclusions Mitomycin-C applied under the scleral flap may have an additional beneficial effect when combined with simultaneous subconjunctival exposure. |
| Databáze: | OpenAIRE |
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