Clonal chromosomal aberrations in a leiomyosarcoma of the sinonasal tract
| Autor: | Leon Barnes, Patrick D. Storto, Susanne M. Gollin, Suguna Sankary, Ivo P. Janecka, Patrick S. Malone, Richard N. Sherwin |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Leiomyosarcoma Cancer Research medicine.medical_specialty Sphenoid Sinus Aneuploidy Biology Genetics medicine Humans Neoplasm Cranial fossa Molecular Biology Chromosome Aberrations Cytogenetics Chromosome Karyotype Sinonasal Tract Anatomy medicine.disease Molecular biology Cranial Fossa Posterior Karyotyping Female Paranasal Sinus Neoplasms |
| Zdroj: | Cancer Genetics and Cytogenetics. 65:21-26 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/0165-4608(93)90053-o |
| Popis: | We report the first cytogenetic analysis of a leiomyosarcoma of the sinonasal tract, a rare neoplasm. Karyotypic analysis showed near-triploid and near-tetraploid modal chromosome numbers with extensive structural and numerical aberrations. Three consistent structural changes, including i(6p), der(10)ins(10;1)(q26;q23q44), and der(12)t(1;12)(q11;q24) were observed in most cells. A der(11)t(11;?)(p15;?) was observed in 14 of 20 cells. Clonal structural rearrangements, including i(1q), del(2)(q37), der(3)t(3;?)(p25;?), del(4)(q31), del(7)(q32), der(12)t(12;?)(p12;?), der(15), del(21)(q22), and der(X) were each observed in a few cells. Numerical changes, including trisomies for chromosomes 2-5, 7, 9, 11, 15, 17, 18, and 20 and monosomies 10 and 12 were observed. Comparison of our findings to those of leiomyosarcomas at different sites showed trisomies 7 and 20 and rearrangements of 11p12-p15 and 21q22. |
| Databáze: | OpenAIRE |
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