Viliuisk encephalomyelitis: intrathecal synthesis of oligoclonal IgG
| Autor: | Alison Green, Vladimir L. Osakovsky, Tatiana M. Sivtseva, M. Zeidler, Lev G. Goldfarb, Colin L. Masters, Vadim G. Krivoshapkin, Al’bina P. Danilova, D. Carleton Gajdusek, Vasiliy P. Alekseev, Feodor A. Platonov, Aleksey Shatunov, Vsevolod A. Vladimirtsev, Richard Knight |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Encephalomyelitis Blotting Western Immunoglobulins Viliuisk encephalomyelitis Sensitivity and Specificity Central nervous system disease Cerebrospinal fluid Degenerative disease Reference Values Medicine Dementia Humans Spasticity Age of Onset Aged Aged 80 and over Cerebral Cortex business.industry Oligoclonal Bands Middle Aged medicine.disease Magnetic Resonance Imaging Neurology Immunology Etiology Female Neurology (clinical) medicine.symptom Isoelectric Focusing business |
| Zdroj: | Journal of the neurological sciences. 212(1-2) |
| ISSN: | 0022-510X |
| Popis: | Viliuisk encephalomyelitis (VE) is a neurodegenerative disorder expressed as subacute meningo-encephalitis progressing to a more prolonged pan-encephalitic syndrome with a fatal outcome within 1 to 10 years. Some patients survive to a steady state of global dementia and severe spasticity that may last for over 20 years. Multiple micronecrotic foci surrounded by inflammatory infiltrates are observed throughout the cerebral cortex and other gray matter areas. Infectious etiology of VE is strongly suspected, but the causative agent has not been identified. We conducted a search for assays that might be helpful for VE diagnosis and established for the first time that the majority of patients with definite VE show evidence for intrathecal IgG synthesis correlating with the clinical manifestations of the disease. This indicates that the detection of oligoclonal IgG banding in the cerebrospinal fluid is a valuable diagnostic assay for VE. Implications of these findings for a possible etiology of VE are discussed. |
| Databáze: | OpenAIRE |
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