Faster-X evolution: Theory and evidence from Drosophila
| Autor: | Brian Charlesworth, Benjamin C. Jackson, José L. Campos |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Mutation rate X Chromosome Population Population genetics Hemizygosity Biology Evolution Molecular 03 medical and health sciences Mutation Rate Genes X-Linked Genetics Animals education Gene Ecology Evolution Behavior and Systematics X chromosome education.field_of_study Autosome Models Genetic Fixation (population genetics) 030104 developmental biology Drosophila Female |
| Zdroj: | Molecular ecology. 27(19) |
| ISSN: | 1365-294X |
| Popis: | A faster rate of adaptive evolution of X-linked genes compared with autosomal genes can be caused by the fixation of recessive or partially recessive advantageous mutations, due to the full expression of X-linked mutations in hemizygous males. Other processes, including recombination rate and mutation rate differences between X chromosomes and autosomes, may also cause faster evolution of X-linked genes. We review population genetics theory concerning the expected relative values of variability and rates of evolution of X-linked and autosomal DNA sequences. The theoretical predictions are compared with data from population genomic studies of several species of Drosophila. We conclude that there is evidence for adaptive faster-X evolution of several classes of functionally significant nucleotides. We also find evidence for potential differences in mutation rates between X-linked and autosomal genes, due to differences in mutational bias towards GC to AT mutations. Many aspects of the data are consistent with the male hemizygosity model, although not all possible confounding factors can be excluded. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text