TheBioGRIDdatabase: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions
| Autor: | Jennifer M. Rust, Andrew Chatr-aryamontri, Chris Stark, Jasmin Coulombe-Huntington, Genie Leung, Andrew Willems, Rose Oughtred, Kara Dolinski, Frederick Zhang, Nadine Kolas, Mike Tyers, Bobby-Joe Breitkreutz, Lorrie Boucher, Christie S. Chang, Sonam Dolma |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Coronavirus disease 2019 (COVID-19)
Databases Factual Computer science phenotype ved/biology.organism_classification_rank.species post‐translational modification Chemical interaction computer.software_genre Biochemistry drug target CRISPR screen 03 medical and health sciences Mice User-Computer Interface Resource (project management) COVID‐19 genetic interaction Protein Interaction Mapping CRISPR Animals Humans protein interaction Model organism Molecular Biology 030304 developmental biology 0303 health sciences biological network Database Tools for Protein Science Cas9 ved/biology chemical interaction SARS-CoV-2 030302 biochemistry & molecular biology ubiquitin‐proteasome system COVID-19 Proteins computer Biological network Genetic screen |
| Zdroj: | Protein Science Protein Science : A Publication of the Protein Society |
| ISSN: | 1469-896X 0961-8368 |
| DOI: | 10.1002/pro.3978 |
| Popis: | The BioGRID (Biological General Repository for Interaction Datasets, thebiogrid.org) is an open‐access database resource that houses manually curated protein and genetic interactions from multiple species including yeast, worm, fly, mouse, and human. The ~1.93 million curated interactions in BioGRID can be used to build complex networks to facilitate biomedical discoveries, particularly as related to human health and disease. All BioGRID content is curated from primary experimental evidence in the biomedical literature, and includes both focused low‐throughput studies and large high‐throughput datasets. BioGRID also captures protein post‐translational modifications and protein or gene interactions with bioactive small molecules including many known drugs. A built‐in network visualization tool combines all annotations and allows users to generate network graphs of protein, genetic and chemical interactions. In addition to general curation across species, BioGRID undertakes themed curation projects in specific aspects of cellular regulation, for example the ubiquitin‐proteasome system, as well as specific disease areas, such as for the SARS‐CoV‐2 virus that causes COVID‐19 severe acute respiratory syndrome. A recent extension of BioGRID, named the Open Repository of CRISPR Screens (ORCS, orcs.thebiogrid.org), captures single mutant phenotypes and genetic interactions from published high throughput genome‐wide CRISPR/Cas9‐based genetic screens. BioGRID‐ORCS contains datasets for over 1,042 CRISPR screens carried out to date in human, mouse and fly cell lines. The biomedical research community can freely access all BioGRID data through the web interface, standardized file downloads, or via model organism databases and partner meta‐databases. |
| Databáze: | OpenAIRE |
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