Enhanced Cellular Immune Response and Reduced CD8+ Lymphocyte Apoptosis in Acutely SIV-Infected Rhesus Macaques after Short-Term Antiretroviral Treatment
| Autor: | Nicole Stolte, Gerhard Hunsmann, D. Lorenzen, Norbert Bischofberger, Ulf Dittmer, Michael Spring, Jonathan L. Heeney, P. J. F. Ten Haaft, Klara Tenner-Racz, Paul Racz, Christiane Stahl-Hennig |
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| Rok vydání: | 2001 |
| Předmět: |
Anti-HIV Agents
Lymphocyte viruses antiretroviral therapy Organophosphonates Simian Acquired Immunodeficiency Syndrome Biology CD8-Positive T-Lymphocytes rhesus macaques Immune system Organophosphorus Compounds Virology medicine Animals Humans Tenofovir Adenine apoptosis T helper cell T-Lymphocytes Helper-Inducer Viral Load Macaca mulatta CTL Disease Models Animal medicine.anatomical_structure Viral replication SIV Apoptosis Immunology Reverse Transcriptase Inhibitors T-helper cell Simian Immunodeficiency Virus Viral load Immunologic Memory CD8 |
| Zdroj: | Virology. 279(1):221-232 |
| ISSN: | 0042-6822 |
| DOI: | 10.1006/viro.2000.0720 |
| Popis: | Losing the decisive virus-specific functions of both CD4(+) and CD8(+) T lymphocytes in the first weeks after immunodeficiency virus infection ultimately leads to AIDS. The SIV/rhesus monkey model for AIDS was used to demonstrate that a 4-week chemotherapeutic reduction of viral load during acute SIV infection of macaques allowed the development of a competent immune response able to control virus replication after discontinuation of treatment in two of five monkeys. Increasing SIV-specific CD4(+) T-helper-cell proliferation was found in all macaques several weeks after treatment, independent of their viral load. However, only macaques with low viral loads showed persistent T-cell reactivity of lymph node cells. In contrast to animals with higher viral loads, T-helper-cell counts and memory T-helper cells did not decline in the two macaques controlling viral replication. Lymphocyte apoptosis was consistently low in all treated macaques. In contrast, high CD8(+) lymphocyte death but only slightly increased CD4(+) lymphocyte apoptosis were observed during the first weeks after infection in untreated control animals, indicating that early apoptotic death of virus-specific CTL could be an important factor for disease development. Antiretroviral treatment early after infection obviously retained virus-specific and competent T lymphocytes, whereby a virus-specific immune response could develop in two animals able to control the viral replication after cessation of treatment. |
| Databáze: | OpenAIRE |
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