Inflammation Markers Correlate With Common Carotid Intima-Media Thickness in Patients Perinatally Infected With Human Immunodeficiency Virus 1

Autor: Antonio Di Biagio, Raffaella Rosso, Paolo Maggi, Debora Mazzei, Claudia Bernardini, Loredana Nulvesu, Andrea Parisini, Elena Nicco, Fabrizio De Carli, Guido Rodriguez, Claudio Viscoli.
Rok vydání: 2013
Předmět:
Zdroj: Journal of ultrasound in medicine (Online) 32 (2013): 763–768. doi:10.7863/ultra.32.5.763.
info:cnr-pdr/source/autori:Antonio Di Biagio; Raffaella Rosso; Paolo Maggi; Debora Mazzei; Claudia Bernardini; Loredana Nulvesu; Andrea Parisini; Elena Nicco; Fabrizio De Carli; Guido Rodriguez; Claudio Viscoli./titolo:Inflammation markers correlate with common carotid intima-media thickness in patients perinatally infected with human immunodeficiency virus 1/doi:10.7863%2Fultra.32.5.763./rivista:Journal of ultrasound in medicine (Online)/anno:2013/pagina_da:763/pagina_a:768/intervallo_pagine:763–768/volume:32
ISSN: 0278-4297
DOI: 10.7863/jum.2013.32.5.763
Popis: Objectives- To investigate common carotid intima-media thickness in a cohort of patients who were vertically infected with human immunodeficiency virus 1 (HIV-1). Methods- We conducted a cross-sectional observational study. Human immunodeficiency virus 1-infected patients were compared with age-, sex-, and body mass index-matched healthy participants. Common carotid intima-media thickness was measured in all participants on both sides of the neck, and the mean intima-media thickness was calculated. Metabolic parameters and markers of inflammation were measured only in HIV-1-infected patients. Statistical analysis was performed by multiple regression and by a matrix of Pearson correlation coefficients. The Student t test was used to compare mean common carotid intima-media thickness values between groups. Results- Forty patients (21 female) with HIV-1 infection acquired from birth with a mean age ± SD of 16.3 ± 4.7 years and 27 healthy participants (11 female) with a mean age of 17.7 ± 4.6 years were included in the study. Mean common carotid intima-media thickness in the HIV-1-infected group (0.450 ± 0.088 mm) was significantly higher (P < .05) than in the control group (0.407 ± 0.079 mm). No significant association was found between intima-media thickness and a specific antiretroviral regimen, exposure to combined antiretroviral agents, and HIV status. In multiple regression analyses, higher levels of insulin (P= .007) and elevated levels of glycated hemoglobin (P= .01) were associated with intima-media thickness changes. Conclusions- Patients perinatally infected with HIV have increased common carotid intima-media thickness compared with healthy individuals. These changes were more pronounced with increasing age and inflammation markers. Interventions that improve cardiovascular risk profiles should be considered in HIV-infected young adults.
Databáze: OpenAIRE
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