Association of Vitamin D deficiency and VDBP gene polymorphism with the risk of AMI in a Pakistani population
| Autor: | Mujtaba Mubashir, Naseema Mehboobali, Mohammad Perwaiz Iqbal, Asal Khan Tareen, Khalida Iqbal, Shaheena Anwar |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Vitamin D-binding protein Vitamin D binding protein genotypes Population Acute myocardial infarction 030204 cardiovascular system & hematology Logistic regression Gastroenterology vitamin D deficiency 03 medical and health sciences 0302 clinical medicine Internal medicine Genotype Vitamin D and neurology Medicine 030212 general & internal medicine education education.field_of_study Vitamin D deficiency business.industry Confounding Pakistani population General Medicine medicine.disease Coronary heart disease Original Article Gene polymorphism business |
| Zdroj: | Pakistan Journal of Medical Sciences |
| ISSN: | 1681-715X |
| Popis: | Objective To investigate the relationship of vitamin D deficiency and risk of AMI in a Pakistani population, and to find out any association between vitamin D binding protein (VDBP) genotypes and risk of AMI in this population. Methods In a comparative cross-sectional study, 246 patients (age: 20-70 years; 171 males and 75 females) with first AMI were enrolled with informed consent. Similarly, 345 healthy adults (230 males and 115 females) were enrolled as controls. Their fasting serum samples were analyzed for 25 (OH) vitamin D, lipids and other biomarkers using kit methods, while DNA was analyzed for VDBP genotypes using PCR-RFLP based methods. Chi-squared test and logistic regression were used for association of vitamin D deficiency and VDBP genotypes with AMI. Results Mean serum concentration of 25(OH) vitamin D was significantly lower in AMI patients compared to healthy subjects (p=0.015) and percent vitamin D deficiency was higher in AMI patients compared to healthy subjects (p=0.003). VDBP IF-IF genotype was positively associated with the risk of AMI in subject above 45 years after adjusting for potential confounders [OR = 9.86; 95% CI=1.16 to 83.43]. Conclusion Vitamin D deficiency and VDBP IF-IF genotype are associated with AMI in Pakistani adults. |
| Databáze: | OpenAIRE |
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