Improved strut coverage and less late incomplete apposition with thin-strut TAXUS Liberté vs. TAXUS Express: the importance of stent platform design for drug-eluting stents
| Autor: | Gregory J. Mishkel, Michael J. Lucca, Mark Turco, Thomas F. McGarry, Jack J. Hall, Chiung-Jen Wu, Neil J. Weissman, Tift Mann, Louis Cannon, Mark Webster, John A. Ormiston, Lazar Mandinov, Keith D. Dawkins |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Neointima medicine.medical_specialty Paclitaxel medicine.medical_treatment Prosthesis Design Coronary Restenosis Double-Blind Method Restenosis Intravascular ultrasound medicine Humans Prospective Studies cardiovascular diseases Ultrasonography Interventional biology medicine.diagnostic_test business.industry Coronary Stenosis Stent Lesion Complexity Cardiovascular Agents Drug-Eluting Stents General Medicine Incomplete stent apposition Middle Aged equipment and supplies biology.organism_classification medicine.disease Coronary Vessels Surgery Apposition Treatment Outcome surgical procedures operative Taxus Female Stents Radiology Tunica Intima Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Cardiovascular Revascularization Medicine. 12:247-257 |
| ISSN: | 1553-8389 |
| DOI: | 10.1016/j.carrev.2010.09.008 |
| Popis: | The objective of this intravascular ultrasound (IVUS) analysis was to evaluate the vascular response of the thin-strut TAXUS Liberté stent compared with the otherwise identical TAXUS Express stent.The TAXUS ATLAS and TAXUS ATLAS Long Lesion studies are nonrandomized trials comparing the thin-strut TAXUS Liberté stent to historical TAXUS Express controls from the TAXUS IV and TAXUS V trials. A total of 377 patients enrolled in the two TAXUS ATLAS studies were randomly selected for the IVUS subset and compared to 314 TAXUS Express IVUS controls.Despite increased lesion complexity in the TAXUS Liberté group, neointimal formation at 9 months was similar in both stents (TAXUS Liberté 13.8±11.0%; TAXUS Express 13.1±13.8%, P=.56). However, this neointima covered more of the overall stent in the TAXUS Liberté (67.9±32.5%) compared with the TAXUS Express (54.4±37.2%, P.001), suggesting more uniform neointimal distribution. TAXUS Liberté also showed less pronounced negative remodeling at both stent edges and had significantly less (4.3% vs. 9.6%, P=.04) late incomplete stent apposition (ISA).Despite identical polymer and drug release characteristic, the thin-strut TAXUS Liberté stent demonstrates improved neointimal coverage, better edge remodeling, and less late ISA vs. TAXUS Express, hereby highlighting the importance of the platform design for drug-eluting stents. |
| Databáze: | OpenAIRE |
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